心脏巨噬细胞代谢在健康和疾病中的作用。
Cardiac macrophage metabolism in health and disease.
机构信息
Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
出版信息
Trends Endocrinol Metab. 2024 Mar;35(3):249-262. doi: 10.1016/j.tem.2023.10.011. Epub 2023 Nov 21.
Cardiac macrophages are essential mediators of cardiac development, tissue homeostasis, and response to injury. Cell-intrinsic shifts in metabolism and availability of metabolites regulate macrophage function. The human and mouse heart contain a heterogeneous compilation of cardiac macrophages that are derived from at least two distinct lineages. In this review, we detail the unique functional roles and metabolic profiles of tissue-resident and monocyte-derived cardiac macrophages during embryonic development and adult tissue homeostasis and in response to pathologic and physiologic stressors. We discuss the metabolic preferences of each macrophage lineage and how metabolism influences monocyte fate specification. Finally, we highlight the contribution of cardiac macrophages and derived metabolites on cell-cell communication, metabolic health, and disease pathogenesis.
心脏巨噬细胞是心脏发育、组织稳态和损伤反应的重要介质。细胞内在的代谢变化和代谢物的可用性调节巨噬细胞的功能。人和小鼠的心脏包含一个异质的心脏巨噬细胞混合物，这些巨噬细胞至少来源于两个不同的谱系。在这篇综述中，我们详细描述了组织驻留巨噬细胞和单核细胞衍生的心脏巨噬细胞在胚胎发育和成人组织稳态以及对病理和生理应激时的独特功能作用和代谢特征。我们讨论了每个巨噬细胞谱系的代谢偏好以及代谢如何影响单核细胞命运的特化。最后，我们强调了心脏巨噬细胞及其衍生代谢物对细胞间通讯、代谢健康和疾病发病机制的贡献。
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