Sato N, Eguchi H, Inoue A, Matsumura T, Kawano S, Kamada T
Adv Exp Med Biol. 1986;200:477-83. doi: 10.1007/978-1-4684-5188-7_59.
We have developed a microscopic analyzing system for studying in vivo hepatic microcirculation, and measured the sinusoidal erythrocyte flow velocity simultaneously in the various sinusoids. With this system and organ reflectance spectrophotometry, the pathophysiological role of microcirculation and of energy metabolism in Zucker fatty rats were studied. The results were as follows: The erythrocyte flow velocity in the predominant sinusoids in the fatty rats was similar to that of the control rats, but the intersinusoidal erythrocyte flow was undetected in the fatty liver. Index of regional hepatic blood volume, regional hepatic blood flow and oxygen saturation of Hb decreased significantly in the fatty rats. The estimated in vivo oxygen consumption was not changed in the fatty liver. From these data, it is concluded that in Zucker fatty rats a marked fatty infiltration causes a decreased hepatic tissue blood flow and volume, but relatively homogeneous erythrocyte flow with an increased extraction of oxygen compensated the decreased vascular beds and maintained normal energy metabolism.
我们开发了一种用于研究体内肝脏微循环的微观分析系统，并同时测量了各种肝血窦内的红细胞流速。利用该系统和器官反射分光光度法，研究了 Zucker 脂肪肝大鼠微循环和能量代谢的病理生理作用。结果如下：脂肪肝大鼠优势肝血窦内的红细胞流速与对照大鼠相似，但在脂肪肝中未检测到肝血窦间的红细胞流动。脂肪肝大鼠的局部肝血容量、局部肝血流量和血红蛋白氧饱和度指数显著降低。脂肪肝中体内估计的氧消耗量没有变化。根据这些数据得出结论，在 Zucker 脂肪肝大鼠中，明显的脂肪浸润导致肝组织血流量和体积减少，但相对均匀的红细胞流动以及增加的氧摄取补偿了血管床的减少并维持了正常的能量代谢。
