Kasahara A, Hayashi N, Kurosawa K, Sasaki Y, Sato N, Kamada T
Hepatology. 1986 Jan-Feb;6(1):87-91. doi: 10.1002/hep.1840060116.
Hepatic blood flow and estimated hepatic oxygen consumption were studied in rats treated chronically with ethanol by organ-reflectance spectrophotometry and the hydrogen clearance method. In the withdrawal state from ethanol, the concentration of hemoglobin in the hepatic tissue (delta Er569-650), the estimated hepatic oxygen consumption (estimated VO2) and the regional liver blood flow decreased significantly in rats treated chronically with ethanol in comparison with their controls. On the other hand, there was no significant difference in the estimated oxygen saturation of the hepatic blood hemoglobin (estimated SO2) between both groups. That is, an increase in oxygen extraction, which was exhibited by a decrease in the estimated SO2, did not occur in rats treated chronically with ethanol in spite of a decrease in blood supply. Thus, in the withdrawal state from ethanol, both oxygen delivery to the liver and oxygen utilization in the liver were disturbed at the stage of alcoholic fatty liver.
采用器官反射分光光度法和氢清除法，对长期用乙醇处理的大鼠的肝血流量和估计的肝氧消耗量进行了研究。在乙醇戒断状态下，与对照组相比，长期用乙醇处理的大鼠肝组织中的血红蛋白浓度（δEr569 - 650）、估计的肝氧消耗量（估计VO2）和局部肝血流量显著降低。另一方面，两组之间肝血血红蛋白的估计氧饱和度（估计SO2）没有显著差异。也就是说，尽管血液供应减少，但长期用乙醇处理的大鼠并没有出现估计SO2降低所表现出的氧摄取增加。因此，在乙醇戒断状态下，在酒精性脂肪肝阶段，肝脏的氧输送和肝脏中的氧利用均受到干扰。
