The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Sci Rep. 2023 Nov 22;13(1):20428. doi: 10.1038/s41598-023-47708-2.
Parkinson's disease (PD) and cardio-cerebrovascular diseases are related, according to earlier studies, but these studies have some controversy. Our aim was to assess the impact of PD on cardiocerebrovascular diseases using a Mendelian randomization (MR) method. The data for PD were single nucleotide polymorphisms (SNPs) from a publicly available genome-wide association study (GWAS) dataset containing data on 482,730 individuals. And the outcome SNPs data is were derived from five different GWAS datasets. The basic method for MR analysis was the inverse variance weighted (IVW) approach. We use the weighted median method and the MR-Egger method to supplement the MR analysis conclusion. Finally, We used Cochran's Q test to test heterogeneity, MR-PRESSO method and leave-one-out analysis method to perform sensitivity analysis. We used ratio ratios (OR) to assess the strength of the association between exposure and outcome, and 95% confidence intervals (CI) to show the reliability of the results. Our findings imply that PD is linked to a higher occurrence of coronary artery disease (CAD) (OR = 1.055, 95% CI 1.020-1.091, P = 0.001), stroke (OR = 1.039, 95% CI 1.007-1.072, P = 0.014). IVW analyses for stroke's subgroups of ischemic stroke (IS) and 95% CI 1.007-1.072, P = 0.014). IVW analyses for stroke's subgroups of ischemic stroke (IS) and cardioembolic stroke (CES) also yielded positive results, respectively (OR = 1.043, 95% CI 1.008-1.079, P = 0.013), (OR = 1.076, 95% CI 1.008-1.149, P = 0.026). There is no evidence of a relationship between PD and other cardio-cerebrovascular diseases. Additionally, sensitivity analysis revealed reliable outcomes. Our MR study analysis that PD is related with an elevated risk of CAD, stroke, IS, and CES.
帕金森病（PD）和心脑血管疾病有关，这是早期研究的结果，但这些研究存在一些争议。我们的目的是使用孟德尔随机化（MR）方法评估 PD 对心脑血管疾病的影响。PD 的数据来自一个公开的全基因组关联研究（GWAS）数据集，其中包含 482730 个人的数据。而结局 SNP 数据来自五个不同的 GWAS 数据集。MR 分析的基本方法是逆方差加权（IVW）方法。我们使用加权中位数法和 MR-Egger 法来补充 MR 分析的结论。最后，我们使用 Cochran's Q 检验来检验异质性，MR-PRESSO 法和逐一剔除分析方法来进行敏感性分析。我们使用比值比（OR）来评估暴露与结局之间的关联强度，95%置信区间（CI）来显示结果的可靠性。我们的研究结果表明，PD 与更高的冠心病（CAD）（OR=1.055，95%CI 1.020-1.091，P=0.001）、中风（OR=1.039，95%CI 1.007-1.072，P=0.014）的发生有关。IVW 分析中风的亚组，包括缺血性中风（IS）和 95%CI 1.007-1.072，P=0.014）。IVW 分析中风的亚组，包括缺血性中风（IS）和心源性栓塞性中风（CES），也分别得出阳性结果（OR=1.043，95%CI 1.008-1.079，P=0.013），（OR=1.076，95%CI 1.008-1.149，P=0.026）。没有证据表明 PD 与其他心脑血管疾病有关。此外，敏感性分析显示结果可靠。我们的 MR 研究分析表明，PD 与 CAD、中风、IS 和 CES 的风险增加有关。
