Chua Shaun Kai Kiat, Saffari Seyed Ehsan, Lee Selene Joon Yan, Tan Eng-King
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
National Neuroscience Institute, Singapore, Singapore.
J Parkinsons Dis. 2022;12(6):1737-1748. doi: 10.3233/JPD-223291.
The relationship between Parkinson's disease (PD) and coronary artery disease (CAD) is unclear.
This study aims to investigate whether PD and CAD are associated through systematic review and meta-analysis of observational studies.
Electronic database search of PubMed, EMBASE, and Web of Science for observational studies published from 1 January 2010 to 1 August 2021 was conducted using terms related to PD and CAD. Unadjusted risk ratios (RR) and odds ratios (OR) of included cohort and case-control studies respectively were used to ascertain the association between PD and CAD. Study heterogeneity was evaluated using the I2 test.
Forty-one full-text studies were initially retrieved for eligibility assessment. Five studies that satisfied the inclusion criteria, consisting of three cohort and two case-control studies, were eventually included in this meta-analysis. The five studies enrolled 35,237 PD patients and 650,866 non-PD patients. PD and CAD were found to be significantly associated in cohort studies (RR = 2.23, 95% CI = 1.08-4.59, p = 0.03; Fig. 2), which held after sensitivity analysis (RR = 1.45, 95% CI = 1.31-1.60, p < 0.001; Fig. 3). Case-control studies found a trend towards association of PD and CAD approaching significance (OR = 1.47, 95% CI = 0.84-2.56, p = 0.18; Fig. 2).
Overall, this meta-analysis suggests that PD is associated with CAD. The underlying mechanisms, as well as the role of ethnicity and other comorbidities on the relationship between PD and CAD should be further explored.
帕金森病（PD）与冠状动脉疾病（CAD）之间的关系尚不清楚。
本研究旨在通过对观察性研究的系统评价和荟萃分析，探讨PD与CAD是否存在关联。
使用与PD和CAD相关的术语，对PubMed、EMBASE和Web of Science电子数据库进行检索，以查找2010年1月1日至2021年8月1日发表的观察性研究。纳入的队列研究和病例对照研究分别采用未调整的风险比（RR）和比值比（OR）来确定PD与CAD之间的关联。使用I²检验评估研究的异质性。
最初检索到41篇全文研究进行资格评估。最终，五项符合纳入标准的研究（包括三项队列研究和两项病例对照研究）被纳入本荟萃分析。这五项研究共纳入35237例PD患者和650866例非PD患者。队列研究发现PD与CAD显著相关（RR = 2.23，95%CI = 1.08 - 4.59，p = 0.03；图2），敏感性分析后结果依然成立（RR = 1.45，95%CI = 1.31 - 1.60，p < 0.001；图3）。病例对照研究发现PD与CAD之间存在关联的趋势，但接近显著性水平（OR = 1.47，95%CI = 0.84 - 2.56，p = 0.18；图2）。
总体而言，本荟萃分析表明PD与CAD相关。潜在机制以及种族和其他合并症在PD与CAD关系中的作用应进一步探讨。
