Chemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Sci Rep. 2023 Nov 22;13(1):20432. doi: 10.1038/s41598-023-47703-7.
A profoundly touchy voltammetric sensor for detection of nicotine (NIC) in urine and tobacco specimens has been developed in light of the boosted electrochemical response of NIC at gold and chitosan nanocomposite modified carbon paste electrode (ACMCPE). Material characterization techniques Scanning Electron Microscope and Energy Dispersive X-ray (SEM & EDX) were utilized to describe the ACMCPE surface material. The impedance spectroscopy technique (EIS), cyclic voltammetry (CV), chronoamperometry (CA), and differential pulse voltammetry (DPV) were employed to explore the electrochemical sensing of NIC at ACMCPE. The created sensor exhibits an exceptional electrochemical sensitivity to NIC in a universal Britton-Robinson (B-R) buffer solution with a pH range of 2.0 to 8.0. The sensor shows a linear response over NIC concentration ranges of 4.0-320.0 µM, with the detection limit (LOD) of 7.6 µM. The prepared sensor has been shown to be exceptionally viable in detecting NIC with amazing selectivity and reproducibility. We suggest it as a trustworthy and useful electrochemical sensor for NIC location.
基于金和壳聚糖纳米复合材料修饰碳糊电极（ACMCPE）上尼古丁（NIC）电化学响应的增强，开发了一种用于检测尿液和烟草样本中尼古丁的灵敏伏安传感器。采用扫描电子显微镜和能谱（SEM 和 EDX）等材料特性描述技术对 ACMCPE 表面材料进行了描述。采用阻抗谱技术（EIS）、循环伏安法（CV）、计时电流法（CA）和差分脉冲伏安法（DPV）研究了 NIC 在 ACMCPE 上的电化学传感性能。在 pH 值范围为 2.0 至 8.0 的通用 Britton-Robinson（B-R）缓冲溶液中，所创建的传感器对 NIC 表现出出色的电化学灵敏度。该传感器在 4.0-320.0 µM 的 NIC 浓度范围内呈现线性响应，检测限（LOD）为 7.6 µM。该制备的传感器在检测 NIC 方面表现出了出色的选择性和重现性，具有很高的可用性。我们建议将其作为一种可靠且有用的电化学传感器用于 NIC 的定位。
