Odegaard S A
Acta Vet Scand. 1986;27(2):243-9. doi: 10.1186/BF03548168.
Proprietary formulations of sulfaphenazole were administered intravenously and orally to sheep. After intravenous injection the disposition of sulfaphenazole was described by an open two compartment model, and the elimination half-time was on average 5.58 h. The apparent volume of distribution was 0.273 1/kg and total body clearance 34.1 ml/kg/h. Judged from the area under the curves, the oral dose was completely absorbed, Drug plasma concentrations versus time fitted an open one compartment model, the half-time of absorption and elimination being 2.66 and 7.12 h, respectively. The binding to plasma proteins was high i.e. 93–96 % at therapeutic concentrations, and concentration dependent. The results demonstrate that the doses indicated by the manufacturer appear to be low and more appropriate for drugs with a longer elimination half-time. Consequently, considerable adjustments in the dosage regimen are recommended.
将磺胺苯吡唑的专利配方通过静脉注射和口服的方式给予绵羊。静脉注射后，磺胺苯吡唑的处置过程可用开放二室模型描述，消除半衰期平均为5.58小时。表观分布容积为0.273升/千克，全身清除率为34.1毫升/千克/小时。从曲线下面积判断，口服剂量被完全吸收，药物血浆浓度与时间的关系符合开放一室模型，吸收半衰期和消除半衰期分别为2.66小时和7.12小时。在治疗浓度下，其与血浆蛋白的结合率很高，即93%-96%，且呈浓度依赖性。结果表明，制造商所指示的剂量似乎偏低，对于消除半衰期较长的药物而言更为合适。因此，建议对给药方案进行大幅调整。
