Department of Histology and Embryology, Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkey.
Department of Biophysics, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
Gen Physiol Biophys. 2023 Nov;42(6):539-549. doi: 10.4149/gpb_2023026.
Sepsis is the host's response to infection and can lead to severe and life-threatening cases. We aimed to investigate the effects of pulsed magnetic field (PMF) on septic liver tissue injury. A total of 28 adult Wistar albino rats were divided equally into four study groups: Sham, PMF-1, PMF-2, and Sepsis, with seven rats in each. Sepsis was performed using the CLP method. PMF-1 and PMF-2 were exposed to 7.5 Hz and 15 Hz PMF, respectively, for 24 hours. After having their livers removed, liver tissues were analysed using histological techniques. We observed remarkable healing in PMF groups. Apoptotic cells decreased in the PMF-treated groups compared with the Sepsis group (p < 0.05). Immune expressions of Acas-3, Bax, and HIF-1 increased in the Sepsis group, while Bcl-2 expression decreased (p < 0.05). The results imply that PMF application has anti-apoptotic, antiinflammatory, and therapeutic effects on septic liver tissue injury.
脓毒症是宿主对感染的反应，可导致严重和危及生命的病例。我们旨在研究脉冲磁场（PMF）对脓毒症肝组织损伤的影响。将 28 只成年 Wistar 白化大鼠平均分为四组：假手术组、PMF-1 组、PMF-2 组和脓毒症组，每组 7 只。采用 CLP 法建立脓毒症模型。PMF-1 组和 PMF-2 组分别暴露于 7.5 Hz 和 15 Hz 的 PMF 中 24 小时。切除肝脏后，采用组织学技术分析肝组织。我们观察到 PMF 组有明显的愈合。与脓毒症组相比，PMF 治疗组的凋亡细胞减少（p < 0.05）。脓毒症组 Acas-3、Bax 和 HIF-1 的免疫表达增加，而 Bcl-2 表达减少（p < 0.05）。结果表明，PMF 应用对脓毒症肝组织损伤具有抗凋亡、抗炎和治疗作用。
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