von der Thüsen Jan
Department of Pathology and Clinical Bioinformatics, Erasmus MC, Rotterdam, The Netherlands.
Histopathology. 2024 Jan;84(1):196-215. doi: 10.1111/his.15097. Epub 2023 Nov 23.
The epithelial and lymphoid compartments of the thymus can give rise to a wide variety of tumours, including thymomas, thymic carcinomas, lymphoreticular proliferations, germ cell tumours, and sarcomas. While some of these have close similarity to their counterparts in other organs, both in terms of histology and immunohistochemistry, as well as molecular features, others are unique to the thymus. The epithelial tumours, which can develop in the thymus, will be discussed in this review, with a particular emphasis on resolving differential diagnosis by means of morphology, immunohistochemical profiles, and molecular diagnostics.
胸腺的上皮和淋巴组织可引发多种肿瘤，包括胸腺瘤、胸腺癌、淋巴网状增生性疾病、生殖细胞肿瘤和肉瘤。其中一些肿瘤在组织学、免疫组织化学以及分子特征方面与其他器官的同类肿瘤极为相似，而另一些则是胸腺所特有的。本文将讨论胸腺中可能发生的上皮性肿瘤，特别强调通过形态学、免疫组织化学特征及分子诊断来解决鉴别诊断问题。
