Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Cancer Sci. 2024 Feb;115(2):623-634. doi: 10.1111/cas.16028. Epub 2023 Nov 23.
Advances in diagnostic techniques and treatment modalities have impacted head and neck cancer (HNC) prognosis, but their effects on subsite-specific prognosis remain unclear. This study aimed to assess subsite-specific trends in mid- and long-term survival for HNC patients diagnosed from 1993 to 2011 using data from population-based cancer registries in Japan. We estimated the net survival (NS) for HNC by subsite using data from 13 prefectural population-based cancer registries in Japan. Changes in survival over time were assessed by multivariate excess hazard model of mortality. In total, 68,312 HNC patients were included in this analysis. We observed an overall improvement in 5-year NS for HNC patients in Japan. However, survival varied among subsites of HNC, with some, such as naso-, oro- and hypopharyngeal cancers, showing significant improvement in both 5- and 10-year NS, whereas others such as laryngeal cancer showed only a slight improvement in 5-year NS and no significant change in 10-year NS after adjustment for age, sex and stage. In conclusion, the study provides insights into changing HNC survival by site at the population level in Japan. Although advances in diagnostic techniques and treatment modalities have improved survival, these improvements are not shared equally among subsites.
诊断技术和治疗方式的进步已经影响了头颈部癌症（HNC）的预后，但它们对亚部位特异性预后的影响仍不清楚。本研究旨在使用日本基于人群的癌症登记处的数据，评估 1993 年至 2011 年间诊断的 HNC 患者的亚部位特异性中、长期生存趋势。我们使用来自日本 13 个都道府县基于人群的癌症登记处的数据，估计了 HNC 按亚部位的净生存率（NS）。通过多变量超额死亡风险模型评估了随时间变化的生存情况。共有 68312 名 HNC 患者纳入本分析。我们观察到日本 HNC 患者的 5 年 NS 总体上有所提高。然而，HNC 的亚部位之间的生存情况存在差异，一些部位，如鼻腔、口腔和下咽癌，在 5 年和 10 年 NS 方面均有显著改善，而其他部位，如喉癌，在 5 年 NS 方面仅略有改善，10 年 NS 则无明显变化，调整了年龄、性别和分期因素后。总之，本研究在日本人群水平上提供了对 HNC 按部位生存变化的深入了解。尽管诊断技术和治疗方式的进步提高了生存率，但这些改进在亚部位之间并不均等。
