MAGI'S LAB, Rovereto (TN), Italy.
Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Clin Ter. 2023 Nov-Dec;174(Suppl 2(6)):230-235. doi: 10.7417/CT.2023.2492.
This scholarly article delves into the multifaceted domains of human cloning, encompassing its biological underpinnings, ethical dimensions, and broader societal implications. The exposition commences with a succinct historical and contextual overview of human cloning, segueing into an in-depth exploration of its biological intri-cacies. Central to this biological scrutiny is a comprehensive analysis of somatic cell nuclear transfer (SCNT) and its assorted iterations. The accomplishments and discoveries in cloning technology, such as successful animal cloning operations and advances in the efficiency and viability of cloned embryos, are reviewed. Future improvements, such as reprogramming procedures and gene editing technology, are also discussed. The discourse extends to ethical quandaries intrinsic to human cloning, entailing an extensive contemplation of values such as human dignity, autonomy, and safety. Furthermore, the ramifications of human cloning on a societal plane are subjected to scrutiny, with a dedicated emphasis on ramifications encompassing personal identity, kinship connections, and the fundamental notion of maternity. Culminating the analysis is a reiteration of the imperative to develop and govern human cloning technology judiciously and conscientiously. Finally, it discusses several ethical and practical issues, such as safety concerns, the possibility of exploitation, and the erosion of human dignity, and emphasizes the significance of carefully considering these issues.
这篇学术文章深入探讨了人类克隆的多方面领域,包括其生物学基础、伦理维度以及更广泛的社会影响。本文首先简要回顾了人类克隆的历史和背景,然后深入探讨了其生物学复杂性。其中,体细胞细胞核转移(SCNT)及其各种变体的综合分析是生物学研究的核心。本文还回顾了克隆技术的成就和发现,例如成功的动物克隆操作以及克隆胚胎效率和活力的提高。此外,还讨论了未来的改进,如重编程程序和基因编辑技术。本文还扩展到了人类克隆所固有的伦理问题,广泛思考了人类尊严、自主性和安全性等价值观。此外,人类克隆对社会层面的影响也受到了审查,特别强调了个人身份、亲属关系和母性基本概念的影响。分析的结论是重申必须明智和认真地开发和管理人类克隆技术。最后,它讨论了一些伦理和实际问题,如安全问题、剥削的可能性和人类尊严的侵蚀,并强调了认真考虑这些问题的重要性。