Int J Oral Implantol (Berl). 2023 Nov 23;16(4):327-336.
Guided bone regeneration is a widely used technique for the treatment of atrophic arches. A broad range of devices have been employed to achieve bone regeneration. The present study aimed to investigate the clinical and histological findings for a new titanium CAD/CAM device for guided bone regeneration, namely semi-occlusive titanium mesh.
Nine partially edentulous patients with vertical and/or horizontal bone defects underwent a guided bone regeneration procedure to enable implant placement. The device used as a barrier was a semi-occlusive CAD/CAM titanium mesh with a laser sintered microperforated scaffold with a pore size of 0.3 mm, grafted with autogenous and xenogeneic bone in a ratio of 80:20. Eight months after guided bone regeneration, surgical and healing complications were evaluated and histological analyses of the regenerated bone were performed.
A total of 9 patients with 11 treated sites were enrolled. Two healing complications were recorded: one late exposure of the device and one early infection (18.18%). At 8 months, well-structured new regenerated trabecular bone with marrow spaces was mostly present. The percentage of newly formed bone was 30.37% ± 4.64%, that of marrow spaces was 56.43% ± 4.62%, that of residual xenogeneic material was 12.16% ± 0.49% and that of residual autogenous bone chips was 1.02% ± 0.14%.
Within the limitations of the present study, the results show that semi-occlusive titanium mesh could be used for vertical and horizontal ridge augmentation. Nevertheless, further follow-ups and clinical and histological studies are required.
引导骨再生是治疗萎缩牙槽骨的常用技术。已经采用了广泛的设备来实现骨再生。本研究旨在研究一种用于引导骨再生的新型钛 CAD/CAM 装置（即半封闭钛网）的临床和组织学发现。
9 名部分无牙患者存在垂直和/或水平骨缺损，接受引导骨再生手术以进行种植体植入。用作屏障的装置是半封闭 CAD/CAM 钛网，带有激光烧结微孔支架，孔径为 0.3mm，以 80:20 的比例移植自体和异种骨。引导骨再生 8 个月后，评估手术和愈合并发症，并对再生骨进行组织学分析。
共纳入 9 名患者，11 个治疗部位。记录了 2 种愈合并发症：一种是晚期装置暴露，一种是早期感染（18.18%）。8 个月时，主要存在结构良好的新再生小梁骨和骨髓腔。新形成骨的百分比为 30.37%±4.64%，骨髓腔的百分比为 56.43%±4.62%，残留异种材料的百分比为 12.16%±0.49%，残留自体骨屑的百分比为 1.02%±0.14%。
在本研究的限制范围内，结果表明半封闭钛网可用于垂直和水平牙槽嵴增量。然而，需要进一步的随访和临床及组织学研究。
