Department of Cardiovascular Surgery, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-Machi, Yufu-Shi, Oita, 879-5593, Japan.
Gen Thorac Cardiovasc Surg. 2024 Jul;72(7):439-446. doi: 10.1007/s11748-023-01988-7. Epub 2023 Nov 23.
The most common complication of thoracic aortic disease with shaggy aorta is cerebral infarction. We have performed "low-flow perfusion" as a method of extracorporeal circulation to prevent cerebral embolism in patients with strong atherosclerotic lesions in the aortic arch.
"Low-flow perfusion" is a method in which cardiopulmonary bypass is started by partial blood removal, approaching deep hypothermia while maintaining self-cardiac output. We compared the outcomes of 12 patients who underwent the "low-flow perfusion" method (Group L) with those of 12 who underwent normal extracorporeal circulation (Group N) during aortic arch surgery since 2019.
Group L consisted of 8 males with an average age of 73 years old, and Group N consisted of 6 males with an average age of 73 years old. The average time from the start of cooling to ventricular fibrillation was 9.5 min in Group L and 3.6 min in Group N (p < 0.01). The eardrum temperature when ventricular fibrillation was reached was 28.2 °C in Group L and 32.5 °C in Group N (p = 0.01). A blood flow analysis also revealed low wall shear stress on the lesser curvature of the aortic arch.
With this method, the intracranial temperature was sufficiently low at the time of ventricular fibrillation, and there was no need to increase the total pump flow. The low-flow perfusion method can prevent cerebral embolism by preventing atheroma destruction by the blood flow jet while maintaining the self-cardiac output during the cooling process.
主动脉疾病伴主动脉毛糙最常见的并发症是脑梗死。我们对主动脉弓部强粥样硬化病变患者采用“低流量灌注”作为体外循环方法,以预防脑栓塞。
“低流量灌注”是一种通过部分血液去除开始心肺转流,同时保持自身心输出量,接近深度低温的方法。我们比较了自 2019 年以来,12 例接受“低流量灌注”方法(L 组)与 12 例接受常规体外循环(N 组)的主动脉弓手术患者的结果。
L 组 8 例为男性,平均年龄 73 岁,N 组 6 例为男性,平均年龄 73 岁。L 组从冷却开始到心室颤动的平均时间为 9.5 分钟,N 组为 3.6 分钟(p<0.01)。达到心室颤动时鼓膜温度,L 组为 28.2°C,N 组为 32.5°C(p=0.01)。血流分析还显示主动脉弓小弯侧的壁面切应力较低。
采用这种方法,在心室颤动时颅内温度足够低,无需增加总泵流量。低流量灌注方法可以通过在冷却过程中保持自身心输出量,同时防止血流喷射破坏动脉粥样硬化斑块,从而预防脑栓塞。