Sein G M
Am J Chin Med. 1986;14(3-4):110-5. doi: 10.1142/S0192415X8600017X.
The effects of gossypol acetic on pregnancy, embryofoetal development and on some selected parameters of immunological response in mice were studied. Daily intragastric administration of gossypol (50 or 75 mg/kg/day) during day 1-15 of gestation in mice produced a dose-dependent embryocidal effect (37.8% and 94.5% respectively) of non-viable foetuses. There was a significant reduction in foetal bodyweight when pregnant mice were treated with gossypol, although no foetal abnormalities were observed. Lymphocyte transformation induced by mitogen concanavalin A, was not inhibited by pretreatment with gossypol (25, 50 or 75 mg/kg/day) for 10 weeks. However, both plaque-forming cells to sheep red blood cell immunisation and the total spleen cell population were significantly depressed by higher doses (50 or 75 mg/kg/day) of gossypol. The results of the present study indicate that gossypol is not teratogenic, but exerts embryocidal and a selective depression on humoral immune response at high dose levels (50 or 75 mg/kg/day). It is not clear, whether the dose-dependent embryocidal and/or immunodepressive effects of gossypol are mediated by the parent compound or its metabolites, or whether these findings have any clinical relevance.
研究了醋酸棉酚对小鼠妊娠、胚胎发育以及某些选定免疫反应参数的影响。在小鼠妊娠第1至15天期间，每日经胃给予棉酚（50或75毫克/千克/天），产生了剂量依赖性的胚胎致死效应（分别为37.8%和94.5%），导致胎儿无法存活。当用棉酚处理妊娠小鼠时，胎儿体重显著降低，尽管未观察到胎儿异常。用棉酚（25、50或75毫克/千克/天）预处理10周，未抑制刀豆球蛋白A诱导的淋巴细胞转化。然而，较高剂量（50或75毫克/千克/天）的棉酚显著降低了针对绵羊红细胞免疫的空斑形成细胞以及脾细胞总数。本研究结果表明，棉酚无致畸性，但在高剂量水平（50或75毫克/千克/天）时具有胚胎致死作用，并对体液免疫反应有选择性抑制作用。尚不清楚棉酚的剂量依赖性胚胎致死和/或免疫抑制作用是由母体化合物还是其代谢产物介导的，也不清楚这些发现是否具有任何临床相关性。
