Department of Dermatology, University Hospitals of Leicester NHS Trust, Leicester, UK.
Bugando Medical Centre, Mwanza, Tanzania.
Clin Exp Dermatol. 2024 Apr 23;49(5):484-490. doi: 10.1093/ced/llad406.
Oculocutaneous albinism (OCA) is a genetically inherited condition, whereby melanin is reduced or absent in the skin. A lack of melanin predisposes people to actinic damage and skin malignancies. In Tanzania, a resource-limited country, the treatment of choice for precancerous skin lesions is cryotherapy.
To investigate whether daylight photodynamic therapy (dPDT) is a safe and well-tolerated treatment for actinic field change in the OCA population in Tanzania.
Twelve participants with actinic damage were recruited from a Standing Voice skin surveillance clinic and treated with dPDT. Study participants completed tolerability and acceptability questionnaires at day 5 and 3 months after treatment. A dermatologist assessed their clinical response to dPDT at 3 months.
dPDT was well-tolerated and acceptable to the majority of patients. Actinic damage was reduced by 25-90%. No skin cancers developed during the treatment.
This pilot study suggests that dPDT is a safe and tolerable treatment for actinic damage in people with OCA in Tanzania. Further work is required to compare the efficacy of dPDT against other topical therapies for actinic field change.
眼皮肤白化病（OCA）是一种遗传性疾病，其特征是皮肤中的黑色素减少或缺失。由于缺乏黑色素，人们容易受到光损伤和皮肤恶性肿瘤的影响。在坦桑尼亚这个资源有限的国家，对癌前皮肤病变的治疗选择是冷冻疗法。
研究日光光动力疗法（dPDT）是否是坦桑尼亚 OCA 人群光暴露部位变化的一种安全且耐受良好的治疗方法。
从 Standing Voice 皮肤监测诊所招募了 12 名患有光损伤的参与者，并对其进行 dPDT 治疗。研究参与者在治疗后第 5 天和第 3 个月完成了耐受性和可接受性问卷调查。皮肤科医生在 3 个月时评估了他们对 dPDT 的临床反应。
dPDT 被大多数患者耐受良好且可接受。光损伤减少了 25-90%。在治疗期间没有发生皮肤癌。
这项初步研究表明，dPDT 是坦桑尼亚 OCA 患者光损伤的一种安全且耐受良好的治疗方法。需要进一步的工作来比较 dPDT 与其他用于光暴露部位变化的局部治疗方法的疗效。
