Shiki Y, Sasaki N, Shirai K, Saito Y, Yoshida S
Am J Chin Med. 1986;14(3-4):138-44. doi: 10.1142/S0192415X86000223.
Studies were made on the effect of phospholipase A2 on the stability of arterial wall lysosomes, and the influence of glycyrrhizin on this effect. Lysosomal phospholipase A2 activity was found to be increased in the aorta of hypercholesterolemic rats. Treatment of the lysosomal fraction of the arterial wall with venom phospholipase A2 resulted in release of acid phosphatase, and addition of glycyrrhizin (0.1 mM) inhibited this release. Lysosomal phospholipase A2 in the arterial wall was also inhibited dose-dependently by glycyrrhizin. These results suggest that lysis of lysosomes was due to increase in phospholipase A2 activity, and that glycyrrhizin stabilized the lysosomes by inhibiting phospholipase A2 activity.
研究了磷脂酶A2对动脉壁溶酶体稳定性的影响，以及甘草酸对该作用的影响。发现高胆固醇血症大鼠主动脉中溶酶体磷脂酶A2活性增加。用蛇毒磷脂酶A2处理动脉壁的溶酶体部分导致酸性磷酸酶释放，加入甘草酸（0.1 mM）可抑制这种释放。甘草酸还对动脉壁中的溶酶体磷脂酶A2有剂量依赖性抑制作用。这些结果表明，溶酶体的裂解是由于磷脂酶A2活性增加，而甘草酸通过抑制磷脂酶A2活性使溶酶体稳定。
