Yousem S A, Hochholzer L
Am J Clin Pathol. 1987 Jan;87(1):1-6. doi: 10.1093/ajcp/87.1.1.
Pulmonary hyalinizing granulomas are distinct fibrosing lesions of lung, having central whorled deposits of lamellar collagen. Twenty-four cases of this unusual pulmonary lesion are reported herein. Hyalinizing granulomas occur in middle-aged persons and are frequently mistaken for metastatic carcinoma radiographically. More than half of the patients had autoimmune phenomena or previous exposures to mycobacterial or fungal antigens. Four patients had sclerosing mediastinitis develop. A progressive debilitating clinical course was related to increasing dyspnea and bilateral disease on chest radiographs. A discussion of the histogenesis and histologic differential diagnosis is presented.
肺透明变性肉芽肿是肺部独特的纤维化病变，有中央层状胶原的漩涡状沉积。本文报告了24例这种不常见的肺部病变。透明变性肉芽肿发生于中年人，在影像学上常被误诊为转移性癌。超过半数的患者有自身免疫现象或既往接触过分枝杆菌或真菌抗原。4例患者发生了硬化性纵隔炎。临床病程呈进行性衰弱，与呼吸困难加重及胸部X线片显示双侧病变有关。本文还对组织发生及组织学鉴别诊断进行了讨论。
