Zhou Yinghui, Seo Jieun, Tu Shan, Nanmo Ayaka, Kageyama Tatsuto, Fukuda Junji
Faculty of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama, Kanagawa 240-8501, Japan.
Faculty of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama, Kanagawa 240-8501, Japan; Institute of Advanced Sciences, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama, Kanagawa, 240-8501, Japan; Kanagawa Institute of Industrial Science and Technology, 3-2-1 Sakado Takatsu-ku, Kawasaki, Kanagawa 213-0012, Japan.
J Biosci Bioeng. 2024 Jan;137(1):1-8. doi: 10.1016/j.jbiosc.2023.11.001. Epub 2023 Nov 23.
Exosomes are lipid bilayer vesicles, 30-200 nm in diameter, that are produced by cells and play essential roles in cell-cell communication. Exosomes have been studied in several medical fields including dermatology. Hair loss, a major disorder that affects people and sometimes causes mental stress, urgently requires more effective treatment. Because the growth and cycling of hair follicles are governed by interactions between hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs), a better understanding of the mechanisms responsible for hair growth and cycling through exosomes may provide new insights into novel treatments for hair loss. In this review, we focused on the comprehensive knowledge and recent studies on exosomes in the field of hair development and regeneration. We classified exosomes of several cellular origins for the treatment of hair loss. Exosomes and their components, such as microRNAs, are promising drugs for effective hair loss treatment.
外泌体是直径为30 - 200纳米的脂质双层囊泡，由细胞产生，在细胞间通讯中发挥重要作用。外泌体已在包括皮肤病学在内的多个医学领域得到研究。脱发是一种影响人们且有时会导致精神压力的主要疾病，迫切需要更有效的治疗方法。由于毛囊的生长和周期受毛囊干细胞（HFSCs）和真皮乳头细胞（DPCs）之间相互作用的调控，通过外泌体更好地了解负责头发生长和周期的机制可能为脱发的新治疗方法提供新见解。在这篇综述中，我们聚焦于毛发发育和再生领域中外泌体的全面知识和最新研究。我们对几种细胞来源的外泌体进行分类以用于脱发治疗。外泌体及其成分，如微小RNA，是有效治疗脱发的有前景的药物。
