Karimi Nazli, Dinçsoy Adnan Berk
Department of Physiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Department of Physiology, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla, Turkey.
Adv Exp Med Biol. 2025;1479:1-17. doi: 10.1007/5584_2024_839.
Skin regeneration, repair, and the promotion of hair growth are intricate and dynamic processes essential for preserving the overall health, functionality, and appearance of both skin and hair. These processes involve a coordinated interplay of cellular activities and molecular signaling pathways that ensure the maintenance and restoration of skin integrity and hair vitality. Recent advancements in regenerative medicine have underscored the significant role of mesenchymal stem cell (MSC)-derived exosomes as key mediators in these processes. Exosomes, emerging as a promising cell-free therapy in tissue engineering, hold substantial potential due to their ability to influence various biological functions. This review explores the mechanisms by which MSC-derived exosomes facilitate skin regeneration and repair, and hair growth, their therapeutic applications, and the future research directions in this emerging field.
皮肤再生、修复以及促进头发生长是复杂且动态的过程，对于维持皮肤和头发的整体健康、功能及外观至关重要。这些过程涉及细胞活动和分子信号通路的协同相互作用，以确保皮肤完整性和头发活力的维持与恢复。再生医学的最新进展突出了间充质干细胞（MSC）衍生的外泌体在这些过程中作为关键介质的重要作用。外泌体作为组织工程中有前景的无细胞疗法崭露头角，因其能够影响多种生物学功能而具有巨大潜力。本文综述探讨了MSC衍生的外泌体促进皮肤再生与修复以及头发生长的机制、它们的治疗应用以及这一新兴领域的未来研究方向。
