National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.
College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.
Neurol Sci. 2024 May;45(5):2261-2270. doi: 10.1007/s10072-023-07193-x. Epub 2023 Nov 23.
Developmental dyslexia (DD) is a neurodevelopmental disorder that is characterized by difficulties with all aspects of information acquisition in the written word, including slow and inaccurate word recognition. The neural basis behind DD has not been fully elucidated.
The study included 22 typically developing (TD) children, 16 children with isolated spelling disorder (SpD), and 20 children with DD. The cortical thickness, folding index, and mean curvature of Broca's area, including the triangular part of the left inferior frontal gyrus (IFGtriang) and the opercular part of the left inferior frontal gyrus, were assessed to explore the differences of surface morphology among the TD, SpD, and DD groups. Furthermore, the structural covariance network (SCN) of the triangular part of the left inferior frontal gyrus was analyzed to explore the changes of structural connectivity in the SpD and DD groups.
The DD group showed higher curvature and cortical folding of the left IFGtriang than the TD group and SpD group. In addition, compared with the TD group and the SpD group, the structural connectivity between the left IFGtriang and the left middle-frontal gyrus and the right mid-orbital frontal gyrus was increased in the DD group, and the structural connectivity between the left IFGtriang and the right precuneus and anterior cingulate was decreased in the DD group.
DD had atypical structural connectivity in brain regions related to visual attention, memory and which might impact the information input and integration needed for reading and spelling.
发育性阅读障碍（DD）是一种神经发育障碍，其特征是书面文字信息获取的各个方面都存在困难，包括单词识别缓慢和不准确。DD 的神经基础尚未完全阐明。
该研究纳入了 22 名正常发育（TD）儿童、16 名单纯拼写障碍（SpD）儿童和 20 名 DD 儿童。评估了 Broca 区皮质厚度、折叠指数和平均曲率，包括左侧额下回三角部（IFGtriang）和左侧额下回眶部，以探讨 TD、SpD 和 DD 组之间表面形态的差异。此外，还分析了左侧额下回三角部的结构协变网络（SCN），以探讨 SpD 和 DD 组结构连接的变化。
DD 组左侧 IFGtriang 的曲率和皮质折叠高于 TD 组和 SpD 组。此外，与 TD 组和 SpD 组相比，DD 组左侧 IFGtriang 与左侧额中回和右侧眶额中回之间的结构连接增加，而 DD 组左侧 IFGtriang 与右侧楔前叶和前扣带回之间的结构连接减少。
DD 患者在与视觉注意力、记忆等相关的脑区存在异常的结构连接，这可能影响阅读和拼写所需的信息输入和整合。
