Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Human Aging, Nanchang, 330031, China.
Ganzhou People's Hospital, Ganzhou, 341000, China.
Cell Commun Signal. 2023 Nov 23;21(1):338. doi: 10.1186/s12964-023-01336-5.
TAR DNA-binding protein 43 (TDP-43) is a versatile RNA/DNA-binding protein with multifaceted processes. While TDP-43 has been extensively studied in the context of degenerative diseases, recent evidence has also highlighted its crucial involvement in diverse life processes beyond neurodegeneration. Here, we mainly reviewed the function of TDP-43 in non-neurodegenerative physiological and pathological processes, including spermatogenesis, embryonic development, mammary gland development, tumor formation, and viral infection, highlighting its importance as a key regulatory factor for the maintenance of normal functions throughout life. TDP-43 exhibits diverse and sometimes opposite functionality across different cell types through various mechanisms, and its roles can shift at distinct stages within the same biological system. Consequently, TDP-43 operates in both a context-dependent and a stage-specific manner in response to a variety of internal and external stimuli. Video Abstract.
TAR DNA 结合蛋白 43（TDP-43）是一种多功能的 RNA/DNA 结合蛋白，具有多方面的作用。虽然 TDP-43 在退行性疾病的背景下已经得到了广泛的研究，但最近的证据也强调了它在神经退行性疾病之外的各种生命过程中的关键作用。在这里，我们主要回顾了 TDP-43 在非神经退行性生理和病理过程中的作用，包括精子发生、胚胎发育、乳腺发育、肿瘤形成和病毒感染，强调了它作为维持生命过程中正常功能的关键调节因子的重要性。TDP-43 通过多种机制在不同的细胞类型中表现出不同的甚至相反的功能，其作用在同一生物系统的不同阶段也会发生变化。因此，TDP-43 在响应各种内部和外部刺激时，以一种依赖于上下文和特定于阶段的方式发挥作用。视频摘要。
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