Department of Biological Sciences, University of Notre Dame, IN, USA.
FEBS J. 2024 Oct;291(19):4159-4192. doi: 10.1111/febs.17012. Epub 2023 Dec 1.
Multiciliated cells (MCCS) form bundles of cilia and their activities are essential for the proper development and physiology of many organ systems. Not surprisingly, defects in MCCs have profound consequences and are associated with numerous disease states. Here, we discuss the current understanding of MCC formation, with a special focus on the genetic and molecular mechanisms of MCC fate choice and differentiation. Furthermore, we cast a spotlight on the use of zebrafish to study MCC ontogeny and several recent advances made in understanding MCCs using this vertebrate model to delineate mechanisms of MCC emergence in the developing kidney.
纤毛细胞（MCCs）形成纤毛束，其活动对于许多器官系统的正常发育和生理功能至关重要。毫不奇怪，MCC 缺陷会产生深远的影响，并与许多疾病状态有关。在这里，我们讨论了 MCC 形成的最新认识，特别关注 MCC 命运选择和分化的遗传和分子机制。此外，我们还重点介绍了使用斑马鱼研究 MCC 个体发生的情况，以及使用这种脊椎动物模型来阐明发育中肾脏中 MCC 出现的机制方面的一些最新进展。
