双响应探针和 DNA 链间交联前体靶向癌细胞的独特氧化还原状态。
Dual-responsive probe and DNA interstrand crosslink precursor target the unique redox status of cancer cells.
机构信息
The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, P. R. China.
Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.
出版信息
Chem Commun (Camb). 2023 Dec 12;59(99):14705-14708. doi: 10.1039/d3cc05175g.
Elevated GSH and HO in cancer cells is sometimes doubted due to their contrary reactivities. Here, we construct a dual-responsive fluorescent probe to confirm the conclusion, and employ this to exploit a redox-inducible DNA interstrand crosslink (ICL) precursor. It crosslinks DNA upon activation by GSH and HO, affording an alternative dual-responsive strategy.
癌细胞中升高的 GSH 和 HO 的反应性相反，因此其存在有时会受到质疑。在这里，我们构建了一种双响应荧光探针来证实这一结论，并利用该探针开发了一种氧化还原诱导的 DNA 链间交联（ICL）前体。该前体在 GSH 和 HO 的激活下交联 DNA，提供了一种替代的双响应策略。
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