Xie Hongxin, Liu Xinyu, Huang Zhengrong, Xu Liexi, Bai Rui, He Fajian, Wang Mengqin, Han Linzhi, Bao Zhirong, Wu Yuzhou, Xie Conghua, Gong Yan
Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Cancers (Basel). 2022 Aug 15;14(16):3935. doi: 10.3390/cancers14163935.
Cancer severely threatens human health and has remained the leading cause of disease-related death for decades. With the rapid advancement of nanomedicine, nanoscale metal-organic frameworks are believed to be potentially applied in the treatment and biomedical imaging for various tumors. Zeolite imidazole framework (ZIF)-8 attracts increasing attention due to its high porosity, large specific surface area, and pH-responsiveness. The designs and modifications of ZIF-8 nanoparticles, as well as the strategy of drug loading, demand a multifaceted and comprehensive understanding of nanomaterial features and tumor characteristics. We searched for studies on ZIF-8-based nanoplatforms in tumor theranostics on Web of Science from 2015 to 2022, mainly focused on the research published in the past 3 years, summarized the progress of their applications in tumor imaging and treatment, and discussed the favorable aspects of ZIF-8 nanoparticles for tumor theranostics as well as the future opportunities and potential challenges. As a kind of metal-organic framework material full of potential, ZIF-8 can be expected to be combined with more therapeutic systems in the future and continue to contribute to all aspects of tumor therapy and diagnosis.
癌症严重威胁人类健康，数十年来一直是疾病相关死亡的主要原因。随着纳米医学的迅速发展，纳米级金属有机框架被认为有可能应用于各种肿瘤的治疗和生物医学成像。沸石咪唑框架（ZIF）-8因其高孔隙率、大比表面积和pH响应性而受到越来越多的关注。ZIF-8纳米颗粒的设计和修饰以及药物负载策略，需要对纳米材料特性和肿瘤特征有多方面的全面理解。我们在科学网（Web of Science）上搜索了2015年至2022年关于基于ZIF-8的纳米平台在肿瘤诊疗中的研究，主要聚焦于过去3年发表的研究，总结了它们在肿瘤成像和治疗中的应用进展，并讨论了ZIF-8纳米颗粒在肿瘤诊疗方面的优势以及未来的机遇和潜在挑战。作为一种极具潜力的金属有机框架材料，预计ZIF-8未来可与更多治疗系统相结合，并继续为肿瘤治疗和诊断的各个方面做出贡献。
