Franks A L, Kendrick J S, Tyler C W
Am J Obstet Gynecol. 1987 Jan;156(1):20-3. doi: 10.1016/0002-9378(87)90196-7.
Previous studies of the association between cigarette smoking and endometrial cancer have yielded inconsistent results. There is some evidence that this discrepancy may be explained by differences in menopausal status between the groups of women studied. We addressed the issue of the effects of postmenopausal smoking on endometrial cancer risk using data from the Cancer and Steroid Hormone Study, a multicenter, population-based, case-control study of gynecologic cancers in the United States. We found that smoking after natural menopause is associated with a 70% reduced risk of endometrial cancer among estrogen users and a 50% reduced risk among nonusers of estrogen. These findings are consistent with previously proposed biologic effects of smoking on estrogen metabolism, which may have important clinical implications.
先前关于吸烟与子宫内膜癌之间关联的研究结果并不一致。有证据表明，这种差异可能是由于所研究女性群体的绝经状态不同所致。我们利用癌症与类固醇激素研究（一项针对美国妇科癌症的多中心、基于人群的病例对照研究）的数据，探讨了绝经后吸烟对子宫内膜癌风险的影响问题。我们发现，自然绝经后吸烟与雌激素使用者患子宫内膜癌的风险降低70%以及非雌激素使用者患子宫内膜癌的风险降低50%相关。这些发现与先前提出的吸烟对雌激素代谢的生物学效应一致，这可能具有重要的临床意义。
