Institute of Neuroscience, UCLouvain, Louvain-la-Neuve, Belgium.
Blood Services, Belgian Red Cross, Mechelen, Belgium.
Vox Sang. 2024 Feb;119(2):134-143. doi: 10.1111/vox.13569. Epub 2023 Nov 24.
Most research studies on the effects of repeated plasma donation are observational with different study limitations, resulting in high uncertainty on the link between repeated plasma donation and health consequences. Here, we prospectively investigated the safety of intensive or less intensive plasma donation protocols.
Sixty-three male subjects participated in this randomized controlled trial and were divided into low-frequency (LF, once/month, n = 16), high-frequency (HF, three times/month, n = 16), very high-frequency (VHF, two times/week, n = 16) and a placebo (P, once/month, n = 15) groups. Biochemical, haematological, clinical, physiological and exercise-related data were collected before (D0), after 1½ months (D42) and after 3 months (D84) of donation.
In VHF, red blood cells, haemoglobin and haematocrit levels decreased while reticulocyte levels increased from D0 to D84. In both HF and VHF, plasma ferritin levels were lower at D42 and D84 compared to D0. In VHF, plasma levels of albumin, immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM) dropped from D0 to D42 and remained lower at D84 than at D0. In HF, plasma IgG, IgA and IgM were lower at D42, and IgG and IgM were lower at D84, compared to D0. Few adverse events were reported in HF and VHF. Repeated plasma donation had no effect on blood pressure, body composition or exercise performance.
VHF plasmapheresis may result in a large reduction in ferritin and IgG levels. HF and VHF plasmapheresis may result in little to no difference in other biochemical, haematological, clinical, physiological and exercise-related parameters.
大多数关于重复献血影响的研究都是观察性的，存在不同的研究局限性，因此在重复献血与健康后果之间的联系方面存在高度不确定性。在这里，我们前瞻性地研究了强化或非强化献血方案的安全性。
63 名男性受试者参加了这项随机对照试验，分为低频（LF，每月一次，n=16）、高频（HF，每月三次，n=16）、超高频（VHF，每周两次，n=16）和安慰剂（P，每月一次，n=15）组。在献血前（D0）、献血后 1.5 个月（D42）和 3 个月（D84）收集了生化、血液学、临床、生理和与运动相关的数据。
在 VHF 组中，从 D0 到 D84，红细胞、血红蛋白和血细胞比容水平下降，网织红细胞水平上升。在 HF 和 VHF 组中，血浆铁蛋白水平在 D42 和 D84 时均低于 D0。在 VHF 组中，从 D0 到 D42，血浆白蛋白、免疫球蛋白 G（IgG）、免疫球蛋白 A（IgA）和免疫球蛋白 M（IgM）水平下降，并且在 D84 时仍低于 D0。在 HF 组中，在 D42 时血浆 IgG、IgA 和 IgM 水平较低，而在 D84 时 IgG 和 IgM 水平较低，与 D0 相比。HF 和 VHF 组报告的不良事件很少。重复献血对血压、身体成分或运动表现没有影响。
VHF 血浆置换可能导致铁蛋白和 IgG 水平大幅下降。HF 和 VHF 血浆置换可能对其他生化、血液学、临床、生理和与运动相关的参数几乎没有影响。
