Ciszewski T S, Ralston S, Acteson D, Wasi S, Strong S J
Canadian Red Cross Society, Blood Transfusion Service, Ontario, Canada.
Transfus Med. 1993 Mar;3(1):59-65. doi: 10.1111/j.1365-3148.1993.tb00105.x.
In order to evaluate the influence of intensity of plasmapheresis on donor serum total protein and immunoglobulin concentrations, these parameters were measured monthly in two groups of plasma donors over a period of 6 months. Donors in group one donated 500-600 ml of plasma at weekly intervals and those in the other groups at intervals of 14 days or longer. Regular whole blood donors were used as a control group. The average concentrations of total protein and IgG immunoglobulin fraction in group one were significantly lower (P < 0.002) than those of the other two groups but they always remained well within the normal ranges. Although the mean total protein level of this group of donors fell significantly during the first 3 months, their values returned to almost baseline levels at the end of the study. No statistically significant difference from the initial concentrations was observed during monthly measurements of IgG, IgA and IgM levels among any of the groups studied. We conclude that removal of 500-600 ml of plasma at weekly intervals involves little, if any, risk of total protein or immunoglobulin depletion in donors who satisfy current criteria. This study also suggests that the frequency of IgG and IgM evaluations may be safely lowered and that IgA determinations may be limited to first time plasma donors.
为了评估血浆置换强度对献血者血清总蛋白和免疫球蛋白浓度的影响，在6个月的时间里，每月对两组血浆献血者的这些参数进行测量。第一组献血者每周捐献500 - 600毫升血浆，另一组献血者每隔14天或更长时间捐献一次。定期全血献血者作为对照组。第一组总蛋白和IgG免疫球蛋白组分的平均浓度显著低于其他两组（P < 0.002），但始终保持在正常范围内。尽管该组献血者的平均总蛋白水平在最初3个月显著下降，但在研究结束时其值几乎恢复到基线水平。在所研究的任何组中，每月测量IgG、IgA和IgM水平时，均未观察到与初始浓度有统计学显著差异。我们得出结论，对于符合当前标准的献血者，每周间隔去除500 - 600毫升血浆，即使有风险，也极少会导致总蛋白或免疫球蛋白耗竭。这项研究还表明，IgG和IgM评估的频率可以安全降低，并且IgA测定可能仅限于首次血浆献血者。
