红细胞分布宽度和D-二聚体在弥漫性大B细胞淋巴瘤中的预后价值：系统评价和荟萃分析
Prognostic value of red blood cell distribution width and D-Dimer in diffuse large B-cell lymphoma: Systematic review and meta-analysis.
作者信息
Rahchamani Maryam, Sedghi Mohammad, Hakimi Ali, Nejatianfar Mahdi, Javaheri Tohid, Tavakoli Reza, Ahmadi Ramtin, Makarem Mansoureh, Azmi-Naei Nazanin, Zahmatkesh Sangani Saeid, Kamandi Neda, Soleimanian AmirMohammad, Shavaleh Rasoul, Foogerdi Molood, Rahmani Kazem
机构信息
Department of Internal Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Molecular and Cellular Biology, Department of Biology, Yadegar-e-Imam Khomeini (RAH) Shahr-e-Ray Branch, Islamic Azad University, Tehran, Iran.
出版信息
Cancer Rep (Hoboken). 2024 Jan;7(1):e1936. doi: 10.1002/cnr2.1936. Epub 2023 Nov 24.
BACKGROUND
The significant role of red blood cell distribution width (RDW) and D-Dimer as prognostic factors in patients with some blood malignancies has been reported recently.
AIM
We designed and performed a meta-analysis to investigate the prognostic roles of RDW and D-Dimer in subjects with diffuse large B-cell lymphoma (DLBCL).
MATERIALS AND METHODS
We systematically reviewed PubMed-Medline, SCOPUS, EMBASE, Web of Science Core Collection, and Google Scholar up to the present to look for publications on prognostic effects of RDW and D-Dimer in DLBCL patients. For investigation of the associations between RDW and D-Dimer with the overall survival (OS) and progression-free survival (PFS) of the DLBCL cases, hazard ratio (HR) with 95% confidence intervals (CIs) was used.
RESULTS
We included 13 eligible studies in the present meta-analysis. The results of pooled analysis showed that increased levels of RDW was related to poor OS (HR = 2.01, 95% CI: 1.62-2.48, p value <.01, I = 0%) and poor PFS (HR = 1.52, 95% CI: 1.24-1.85, p value <.01, I = 16%) among the DLBCL patients. Similarly, a significant relationship was found between increased D-Dimer and poor OS (HR = 2.30, 95% CI: 1.03-5.14, p value <.05, I = 95%) of the DLBCL patients as well. In addition, there was no significant heterogeneity in OS (p value H = 0.65) and PFS (p value H = 0.31) related to RDW among studies included in the meta-analysis.
CONCLUSION
Our finding clearly confirmed that elevated RDW levels and D-Dimer were associated with adverse OS and PFS in DLBCL.
背景
近期有报道称，红细胞分布宽度（RDW）和D - 二聚体作为某些血液系统恶性肿瘤患者的预后因素具有重要作用。
目的
我们设计并进行了一项荟萃分析，以研究RDW和D - 二聚体在弥漫性大B细胞淋巴瘤（DLBCL）患者中的预后作用。
材料与方法
我们系统检索了截至目前的PubMed - Medline、SCOPUS、EMBASE、Web of Science核心合集和谷歌学术，以查找关于RDW和D - 二聚体对DLBCL患者预后影响的出版物。为了研究RDW和D - 二聚体与DLBCL病例的总生存期（OS）和无进展生存期（PFS）之间的关联，我们使用了具有95%置信区间（CI）的风险比（HR）。
结果
在本次荟萃分析中，我们纳入了13项符合条件的研究。汇总分析结果显示，DLBCL患者中RDW水平升高与较差的OS（HR = 2.01，95% CI：1.62 - 2.48，p值 <.01，I² = 0%）和较差的PFS（HR = 1.52，95% CI：1.24 - 1.85，p值 <.01，I² = 16%）相关。同样，DLBCL患者中D - 二聚体升高与较差的OS（HR = 2.30，95% CI：1.03 - 5.14，p值 <.05，I² = 95%）之间也发现了显著关系。此外，在荟萃分析纳入的研究中，与RDW相关的OS（p值H = 0.65）和PFS（p值H = 0.31）不存在显著异质性。
结论
我们的研究结果明确证实，DLBCL中RDW水平升高和D - 二聚体与不良的OS和PFS相关。
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