Ursu Ștefan, Ciocan Andra, Ursu Cristina-Paula, Gherman Claudia Diana, Ciocan Răzvan Alexandru, Pop Rodica Sorina, Spârchez Zeno, Zaharie Florin, Al Hajjar Nadim
Department of Surgery, "Iuliu Hațieganu" University of Medicine and Pharmacy, Croitorilor Street, No. 19-21, 400162 Cluj-Napoca, Romania.
"Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology, Croitorilor Street, No. 19-21, 400162 Cluj-Napoca, Romania.
Diagnostics (Basel). 2023 Nov 8;13(22):3401. doi: 10.3390/diagnostics13223401.
Gastric cancer is the fourth most frequently diagnosed form of cancer and the third leading cause of cancer-related mortality worldwide. The aim of this review is to identify individual metabolic biomarkers and their association with accurate diagnostic values, which can predict gastric cancer metastasis.
After searching the keywords, 83 articles were found over a period of 13 years. One was eliminated because it was not written in English, and two were published outside the selected period. Seven scientific papers were qualified for this investigation after eliminating duplicates, non-related articles, systematic reviews, and restricted access studies.
New metabolic biomarkers with predictive value for gastric cancer metastasis and for elucidating metabolic pathways of the metastatic process have been found. The pathogenic processes can be outlined as follows: pro-oxidant capacity, T-cell inactivation, cell cycle arrest, energy production and mitochondrial enzyme impairment, cell viability and pro-apoptotic effect, enhanced degradation of collagen extracellular matrix, migration, invasion, structural protein synthesis, and tumoral angiogenesis.
Metabolic biomarkers have been recognized as independent risk factors in the molecular process of gastric cancer metastasis, with good diagnostic and prognostic value.
胃癌是全球第四大常见癌症诊断类型，也是癌症相关死亡的第三大主要原因。本综述的目的是确定个体代谢生物标志物及其与准确诊断价值的关联，这些生物标志物能够预测胃癌转移。
在搜索关键词后，13年间共找到83篇文章。其中1篇因非英文撰写被排除，2篇发表于选定时间段之外。在排除重复文章、不相关文章、系统评价和受限访问研究后，7篇科学论文符合本调查要求。
已发现对胃癌转移具有预测价值且有助于阐明转移过程代谢途径的新代谢生物标志物。致病过程可概述如下：促氧化能力、T细胞失活、细胞周期停滞、能量产生及线粒体酶损伤、细胞活力及促凋亡作用、胶原细胞外基质降解增强、迁移、侵袭、结构蛋白合成及肿瘤血管生成。
代谢生物标志物已被确认为胃癌转移分子过程中的独立危险因素，具有良好的诊断和预后价值。
