UCLA School of Dentistry, Los Angeles, CA, USA.
UCLA School of Medicine, Los Angeles, CA, USA.
Adv Exp Med Biol. 2021;1280:291-301. doi: 10.1007/978-3-030-51652-9_20.
Gastric cancer is the fourth most common malignancy worldwide and the third leading cause of cancer deaths. Recent metabolomics research has advanced our understanding of the relationship between metabolic reprogramming and gastric cancer progression and led to the discovery of metabolic targets for potential clinical applications and therapeutic interventions. As a powerful tool for metabolite and flux measurement, metabolomics not only allows a comprehensive analysis of metabolites and related metabolic pathways but also can investigate the interactions between gastric cancer cells and tumour microenvironment as well as between the cancer cells and gastric microbiome. In this chapter, we aim to summarize the recent advances in gastric cancer metabolism and discuss the applications of metabolomics for target discovery in gastric cancer.
胃癌是全球第四大常见恶性肿瘤，也是癌症死亡的第三大主要原因。最近的代谢组学研究增进了我们对代谢重编程与胃癌进展之间关系的理解，并发现了代谢靶点，为潜在的临床应用和治疗干预提供了可能。作为一种用于测量代谢物和通量的强大工具，代谢组学不仅可以全面分析代谢物和相关代谢途径，还可以研究胃癌细胞与肿瘤微环境之间以及癌细胞与胃微生物组之间的相互作用。在本章中，我们旨在总结胃癌代谢的最新进展，并讨论代谢组学在胃癌靶点发现中的应用。
