Huang Haiyun, Li Xiaojun, Deng Yican, San Siyi, Qiu Dongmei, Guo Xiaoyu, Xu Lingyun, Li Yang, Zhang Hongling, Li Yuanyuan
School of Medicine and Health, Wuhan Polytechnic University, Wuhan 430023, China.
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Toxics. 2023 Nov 2;11(11):897. doi: 10.3390/toxics11110897.
This study investigates the association between prenatal exposure to per- and polyfluoroalkyl substances (PFASs) and the incidence and frequency of respiratory tract infections (RTIs) in preschool children. We selected 527 mother-infant pairs from Wuhan Healthy Baby Cohort (WHBC), China. Ten PFASs were measured in umbilical cord serum, and we collected data on common RTIs in preschool children aged 4 years through a questionnaire. Associations of single PFASs with the incidence and frequency of RTIs were analyzed via Logistic regression and Poisson regression, while the collective effect was assessed by weighted quantile sum (WQS) regression. Furthermore, stratified and interaction analyses were performed to evaluate if there were sex-specific associations. We found a positive correlation between perfluorododecanoic acid (PFDoDA) and the incidence of tonsillitis, with several PFASs also showing positive associations with its frequency. Moreover, perfluorotridecanoic acid (PFTrDA) showed a positive link with the frequency of common cold. The results of WQS regression revealed that after adjusting for other covariates, PFASs mixture showed a positive association with the incidence of tonsillitis, the frequency of common cold, and episodes. In particular, perfluoroundecanoic acid (PFUnDA), PFDoDA, PFTrDA, perfluorodecanoic acid (PFDA) and 8:2 chlorinated polyfluorinated ether sulfonic acid (8:2 Cl-PFESA) had the most significant impact on this combined effect. The results suggest that both single and mixed exposures to PFASs may cause RTIs in preschool children. However, there was no statistically significant interaction between different PFASs and sex.
本研究调查了产前暴露于全氟和多氟烷基物质（PFASs）与学龄前儿童呼吸道感染（RTIs）的发病率及发病频次之间的关联。我们从中国武汉健康婴儿队列（WHBC）中选取了527对母婴。检测了脐带血血清中的10种PFASs，并通过问卷收集了4岁学龄前儿童常见RTIs的数据。通过逻辑回归和泊松回归分析了单一PFASs与RTIs发病率及发病频次的关联，同时通过加权分位数和（WQS）回归评估了总体效应。此外，进行了分层分析和交互分析以评估是否存在性别特异性关联。我们发现全氟十二烷酸（PFDoDA）与扁桃体炎发病率呈正相关，几种PFASs与其发病频次也呈正相关。此外，全氟十三烷酸（PFTrDA）与普通感冒的发病频次呈正相关。WQS回归结果显示，在调整其他协变量后，PFASs混合物与扁桃体炎发病率、普通感冒发病频次及发作次数呈正相关。特别是，全氟十一烷酸（PFUnDA）、PFDoDA、PFTrDA、全氟癸酸（PFDA）和8:2氯代多氟醚磺酸（8:2 Cl-PFESA）对这种综合效应影响最为显著。结果表明，单一暴露和混合暴露于PFASs均可能导致学龄前儿童发生RTIs。然而，不同PFASs与性别之间未发现具有统计学意义的交互作用。
