Fiorelli Denise, Romani Leonardo, Treglia Michele, Pallocci Margherita, Passalacqua Pierluigi, Coppeta Luca, Marsella Luigi Tonino, Tittarelli Roberta
Laboratory of Forensic Toxicology, Section of Legal and Forensic Medicine, Social Security and Forensic Toxicology, Department of Biomedicine and Prevention, Faculty of Medicine and Surgery, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
PhD School in Medical-Surgical Applied Sciences, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
Toxics. 2023 Nov 7;11(11):914. doi: 10.3390/toxics11110914.
Alcohol abuse is still one of the leading causes of death worldwide. Early diagnosis of alcohol abuse enables preventive intervention on the effects and risks associated with its consumption. Carbohydrate-deficient transferrin (CDT) is one of the most reliable biomarkers of chronic alcohol misuse. We retrospectively studied a population of 12,624 subjects who had their driving license suspended for driving under the influence of alcohol or drugs from 2016 to 2022. The analytical determination of CDT was performed following a certified high-performance liquid chromatography (HPLC) method. Data were split by year, age and gender. The majority of subjects with positive %CDT were male, although the trend of positivity was similar between males and females. A steady increase in both the number of tests performed and the number of positives was observed over the years. Patients aged 41-50 years had the highest prevalence, followed by 51-60, 31-40 and 18-30 years. CDT continues to be a steady marker for diagnosis of alcohol abuse in the majority of cases. Data emerging from our study are in line with the increasing national trends on traffic accidents, injuries and deaths related to alcohol and drug DUI (driving under the influence), requiring the implementation of preventive measures to limit this ever-growing phenomenon.
酒精滥用仍是全球主要死因之一。酒精滥用的早期诊断有助于对与饮酒相关的影响和风险进行预防性干预。缺糖转铁蛋白（CDT）是慢性酒精滥用最可靠的生物标志物之一。我们回顾性研究了2016年至2022年期间因酒后或吸毒驾驶而被吊销驾照的12624名受试者。CDT的分析测定采用经过认证的高效液相色谱（HPLC）方法。数据按年份、年龄和性别进行划分。%CDT呈阳性的受试者大多数为男性，不过男性和女性的阳性趋势相似。多年来，检测次数和阳性人数均稳步增加。41至50岁的患者患病率最高，其次是51至60岁、31至40岁和18至30岁的患者。在大多数情况下，CDT仍然是诊断酒精滥用的稳定标志物。我们研究得出的数据与全国范围内与酒精和药物酒驾（在影响下驾驶）相关的交通事故、伤害和死亡人数不断增加的趋势一致，这就需要实施预防措施来限制这一不断增长的现象。
