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用于为生物医学植入物供电的小型化低频磁电无线功率传输系统。

A Miniaturized, Low-Frequency Magnetoelectric Wireless Power Transfer System for Powering Biomedical Implants.

出版信息

IEEE Trans Biomed Circuits Syst. 2024 Apr;18(2):438-450. doi: 10.1109/TBCAS.2023.3336598. Epub 2024 Apr 1.

Abstract

This work experimentally demonstrates the operation of a miniaturized magnetoelectric (ME) wireless power transfer (WPT) system by incorporating a ME transducer and a suitable interface power management circuit (PMC) for potentially powering implantable medical devices (IMD) wirelessly. A ME heterostructure is micromachined to obtain desired device dimensions of 3.5 × 5 mm and to restrict the operating frequency at a clinically approved frequency of 50 kHz. The proposed work also aims to address the trade-off between the device miniaturization, power attenuation and limiting the specific absorption rate (SAR) in the human tissue. By limiting the operating frequency to 50 kHz, the SAR is reduced to less than 1 μW/kg. The fabricated device is characterized with low-intensity AC magnetic field up to 40 μT without using any DC bias, resulting in 0.4 V output voltage and 6.6 μW power across 8 k Ω load. Alignment misorientation between the Tx and Rx is studied for in-plane and out-of-plane angular rotations to confirm the device's reliability against angular misalignment. By eliminating the bulky biasing magnets, the proposed device achieves a significant size reduction compared to the previously reported works. In addition, a self-powered interface PMC is incorporated with the ME system. The PMC generates 3.5 V regulated DC voltage from the input AC voltage range 0.7 V to 3.3 V. The PMC is fabricated on a 2-layered PCB and the over all ME WPT system consumes 12 × 12 mm area. The overall PMC has intrinsic current consumption less than 550 nA with peak power conversion efficiency higher than 85 %. The in vitro cytotoxicity analysis in the human hepatic cell line WRL-68 confirmed the biocompatibility of the Parylene-C encapsulated ME device for up to 7 days, suggesting its potential use in implantable electronic devices for biomedical and clinical applications.

摘要

这项工作通过结合磁电(ME)换能器和合适的接口电源管理电路(PMC),实验性地演示了一个小型化的 ME 无线功率传输(WPT)系统的运行,以实现对植入式医疗设备(IMD)的无线供电。一个 ME 异质结构被微加工,以获得所需的器件尺寸 3.5×5mm,并将工作频率限制在临床认可的 50kHz 频率。这项工作还旨在解决器件小型化、功率衰减和限制人体组织中比吸收率(SAR)之间的权衡问题。通过将工作频率限制在 50kHz,SAR 降低到小于 1μW/kg。该制造的器件具有低强度交流磁场,可达 40μT,无需使用任何直流偏置,从而在 8kΩ负载下产生 0.4V 的输出电压和 6.6μW 的功率。研究了 Tx 和 Rx 之间的对准失配,以验证器件在平面内和平面外角度旋转时的可靠性。通过消除大块偏置磁铁,与以前报道的工作相比,该器件实现了显著的尺寸减小。此外,一个自供电接口 PMC 与 ME 系统结合在一起。PMC 从输入交流电压范围 0.7V 到 3.3V 生成 3.5V 稳压直流电压。PMC 是在 2 层 PCB 上制造的,整个 ME WPT 系统消耗 12×12mm 的面积。整体 PMC 的固有电流消耗小于 550nA,峰值功率转换效率高于 85%。在人肝细胞系 WRL-68 中的体外细胞毒性分析证实了聚对二甲苯封装 ME 器件的生物相容性,最长可达 7 天,这表明它在植入式电子设备中的潜在应用,用于生物医学和临床应用。

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