Institute of Pharmaceutical Science, Kurukshetra University, Kurukshetra, India.
Int J Toxicol. 2024 Jan-Feb;43(1):63-71. doi: 10.1177/10915818231216414. Epub 2023 Nov 24.
Hydrotropic solubilization is a technique that can be used to improve the solubility of drugs that are poorly soluble. This technique involves adding a large amount of a second solute, known as a hydrotrope, which increases the aqueous solubility of the poorly soluble drug. Hydrotropes such as sodium citrate, sodium benzoate, and urea have been shown to be effective in enhancing the solubility of poorly soluble drugs. This technique has several advantages over other solubility enhancement techniques, including its cost-effectiveness, eco-friendliness, and the fact that it does not require chemical modification of hydrophobic drugs or the use of organic solvents. Hydrotropic agents are now being used to develop various dosage forms, including solid dispersions, mouth-dissolving tablets, and injections, to improve poorly water-soluble drugs' therapeutic effectiveness and bioavailability. This review paper will provide an overview of hydrotropic solubilization techniques.
水溶增溶技术是一种可以用来提高难溶性药物溶解度的技术。该技术涉及添加大量的第二种溶质，即所谓的水溶助剂，以增加难溶性药物的水溶解度。已证明柠檬酸钠、苯甲酸钠和尿素等水溶助剂在提高难溶性药物的溶解度方面非常有效。与其他提高溶解度的技术相比，该技术具有成本效益高、环保、不需要对疏水性药物进行化学修饰或使用有机溶剂等优点。水溶助剂现正被用于开发各种剂型，包括固体分散体、口溶片和注射剂，以提高水溶性差的药物的治疗效果和生物利用度。本文综述了水溶增溶技术。
