Precision Medicine & Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen, China; National Engineering Research Center of Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, China.
National Engineering Research Center of Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, China.
Neurosurg Clin N Am. 2024 Jan;35(1):105-118. doi: 10.1016/j.nec.2023.09.005.
As the pathophysiological mechanisms of vagus nerve stimulation (VNS) causing individual differences in the vagal ascending network remains unclear, stereoelectroencephalography (SEEG) provides a unique platform to explore the brain networks affected by VNS and helps to understand the anti-seizure mechanism of VNS more comprehensively. This study presents a preliminary exploration of the acute effect of VNS. SEEG signals were collected to assess the acute effect of VNS on neural synchronization in patients with drug-resistant epilepsy, especially in epileptogenic networks. The results show that the better the efficacy of VNS, the wider the spread of desynchronization assessed by weighted phase lag index at a high frequency band caused by VNS. Future studies should focus on the association between the change in synchronization and the efficacy of VNS, exploring the possibility of synchronization as a biomarker for patient screening and parameter programming.
由于迷走神经刺激（VNS）引起迷走神经上行网络个体差异的病理生理机制尚不清楚，立体脑电图（SEEG）提供了一个独特的平台来探索受 VNS 影响的脑网络，并有助于更全面地了解 VNS 的抗癫痫机制。本研究初步探讨了 VNS 的急性效应。采集 SEEG 信号，以评估 VNS 对耐药性癫痫患者神经同步的急性影响，特别是在致痫网络中。结果表明，VNS 效果越好，由 VNS 引起的高频带加权相位滞后指数评估的去同步传播范围越广。未来的研究应集中在同步变化与 VNS 疗效之间的关联上，探索同步作为患者筛选和参数编程的生物标志物的可能性。
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