Ren Yanming, Mao Shuifang, Zeng Yujun, Chen Shiguo, Tian Jinhu, Ye Xingqian
College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.
Zhongyuan Institute, Zhejiang University, Zhengzhou 450000, China.
Foods. 2023 Nov 11;12(22):4094. doi: 10.3390/foods12224094.
The effects of pectin from Marc. on glycolipid metabolism, the morphologies of the pancreas and epididymal fat, the gut microbiota, and the metabolites of short-chain fatty acids (SCFAs) in db/db mice were investigated in this study. The results indicated that pectin reduced the levels of fasting blood glucose, glycated serum protein, triglycerides, total cholesterol, and low-density lipoprotein cholesterol while increasing the levels of high-density lipoprotein cholesterol. Meanwhile, pectin could improve the morphology of islet cells and inhibit the hypertrophy of adipocytes. Additionally, pectin not only regulated the intestinal flora dysbiosis in db/db mice, as shown by the increasing proportion of / and the relative abundance of , , and , but also remedied the metabolic disorder of SCFAs in db/db mice. These results suggest that pectin could promote glucose and lipid metabolism by regulating the intestinal flora with changes in SCFA profile. This study proves that pectin might serve as a new prebiotic agent to prevent the disorder of glycolipid metabolism.
本研究考察了来自[具体来源不明，推测为某种植物，Marc.可能是缩写]的果胶对db/db小鼠糖脂代谢、胰腺和附睾脂肪形态、肠道微生物群以及短链脂肪酸（SCFAs）代谢产物的影响。结果表明，果胶降低了空腹血糖、糖化血清蛋白、甘油三酯、总胆固醇和低密度脂蛋白胆固醇水平，同时提高了高密度脂蛋白胆固醇水平。此外，果胶可改善胰岛细胞形态并抑制脂肪细胞肥大。另外，果胶不仅调节了db/db小鼠肠道菌群失调，表现为[此处/及相关微生物名称不完整，无法准确翻译]比例增加以及[相关微生物名称]相对丰度增加，还纠正了db/db小鼠SCFAs的代谢紊乱。这些结果表明，果胶可通过调节肠道菌群及SCFA谱变化促进糖脂代谢。本研究证明，果胶可能作为一种新型益生元制剂预防糖脂代谢紊乱。
