Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305-5101, USA.
Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, 2730 Herlev, Denmark.
Biomolecules. 2023 Nov 6;13(11):1620. doi: 10.3390/biom13111620.
Colorectal cancer is a known complication of chronic inflammation of the colon ("colitis-associated colon cancer"). Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Patients with IBD are at increased risk of colon cancer compared to the general population. Kinase signaling pathways play critical roles in both the inflammation and regulating cellular processes such as proliferation and survival that contribute to cancer development. Here we review the interplay of kinase signaling pathways (mitogen-activated protein kinases, cyclin-dependent kinases, autophagy-activated kinases, JAK-STAT, and other kinases) and their effects on colitis-associated colon cancer. We also discuss the role of JAK-STAT signaling in the pathogenesis of IBD and the therapeutic landscape of JAK inhibitors for the treatment of IBD.
结直肠癌是结肠慢性炎症（“结肠炎相关结肠癌”）的已知并发症。炎症性肠病（IBD）是一种胃肠道慢性炎症性疾病。与普通人群相比，IBD 患者患结肠癌的风险增加。激酶信号通路在炎症和调节细胞过程（如增殖和存活）中发挥关键作用，这些过程有助于癌症的发展。在这里，我们回顾了激酶信号通路（丝裂原活化蛋白激酶、细胞周期蛋白依赖性激酶、自噬激活激酶、JAK-STAT 和其他激酶）的相互作用及其对结肠炎相关结肠癌的影响。我们还讨论了 JAK-STAT 信号在 IBD 发病机制中的作用以及 JAK 抑制剂治疗 IBD 的治疗前景。
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