非编码 RNA 作为口腔扁平苔藓诊断和治疗的潜在靶点：一项叙述性综述。

Non-Coding RNAs as Potential Targets for Diagnosis and Treatment of Oral Lichen Planus: A Narrative Review.

机构信息

Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.

Department of Oral Medicine, Institute of Oral Bioscience, School of Dentistry, Jeonbuk National University, Jeonju 54896, Republic of Korea.

出版信息

Biomolecules. 2023 Nov 13;13(11):1646. doi: 10.3390/biom13111646.

DOI:10.3390/biom13111646

PMID:38002328

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10669845/

Abstract

Oral lichen planus (OLP) is a chronic inflammatory disease that is characterized by the infiltration of T cells into the oral mucosa, causing the apoptosis of basal keratinocytes. OLP is a multifactorial disease of unknown etiology and is not solely caused by the malfunction of a single key gene but rather by various intracellular and extracellular factors. Non-coding RNAs play a critical role in immunological homeostasis and inflammatory response and are found in all cell types and bodily fluids, and their expression is closely regulated to preserve normal physiologies. The dysregulation of non-coding RNAs may be highly implicated in the onset and progression of diverse inflammatory disorders, including OLP. This narrative review summarizes the role of non-coding RNAs in molecular and cellular changes in the oral epithelium during OLP pathogenesis.

摘要

口腔扁平苔藓（OLP）是一种慢性炎症性疾病，其特征是 T 细胞浸润口腔黏膜，导致基底角质形成细胞凋亡。OLP 是一种病因不明的多因素疾病，并非仅由单个关键基因功能障碍引起，而是由各种细胞内和细胞外因素引起的。非编码 RNA 在免疫稳态和炎症反应中起着至关重要的作用，存在于所有细胞类型和体液中，其表达受到严格调控以维持正常生理功能。非编码 RNA 的失调可能与多种炎症性疾病（包括 OLP）的发生和发展密切相关。本综述总结了非编码 RNA 在 OLP 发病机制中口腔上皮细胞分子和细胞变化中的作用。