Department of Pathology, Stomatology College of Shandong University, 44-1#, Wenhua Xi Road, Jinan, Shandong, 250012, People's Republic of China.
J Clin Immunol. 2011 Oct;31(5):827-39. doi: 10.1007/s10875-011-9552-4. Epub 2011 Jun 14.
Oral lichen planus is a chronic inflammatory disorder of the oral mucosa that represents T cell-mediated autoimmune diseases. The regulation and roles of carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1), a novel immune molecule, in the immunopathogenesis of T cell-mediated autoimmune diseases remain unclear. In the current paper, CEACAM1 was found to be overexpressed in peripheral T cells and epithelial cells in oral lichen planus patients. A fraction of infiltrating inflammatory mononuclear cells in the lamina propria of the oral lichen planus mucosa also expressed CEACAM1. Importantly, for the first time, CEACAM1 expression in T cells and in normal human oral keratinocytes was demonstrated to be regulated differently by osteopontin in vitro. Furthermore, the apoptosis of oral keratinocytes and activated T cells can be markedly suppressed by CEACAM1-specific monoclonal antibodies. In conclusion, OPN-regulated CEACAM1 expression may play a critical role in the immunopathogenesis of oral lichen planus.
口腔扁平苔藓是一种口腔黏膜的慢性炎症性疾病，代表 T 细胞介导的自身免疫性疾病。癌胚抗原相关细胞黏附分子 1（CEACAM1）是一种新型免疫分子，其在 T 细胞介导的自身免疫性疾病的免疫发病机制中的调节和作用尚不清楚。在本论文中，发现 CEACAM1 在口腔扁平苔藓患者的外周 T 细胞和上皮细胞中过度表达。口腔扁平苔藓黏膜固有层中浸润的炎症性单核细胞的一部分也表达 CEACAM1。重要的是，首次证明骨桥蛋白在体外可调节 T 细胞和正常人口腔角质形成细胞中 CEACAM1 的表达。此外，口腔角质形成细胞和活化 T 细胞的凋亡可以被 CEACAM1 特异性单克隆抗体显著抑制。总之，OPN 调节的 CEACAM1 表达可能在口腔扁平苔藓的免疫发病机制中起关键作用。
