Li Peng, Laudato Marco, Mihaescu Mihai
Department of Engineering Mechanics, FLOW, KTH Royal Institute of Technology, 10044 Stockholm, Sweden.
Bioengineering (Basel). 2023 Nov 14;10(11):1313. doi: 10.3390/bioengineering10111313.
Obstructive Sleep Apnea Syndrome (OSAS) is a common sleep-related disorder. It is characterized by recurrent partial or total collapse of pharyngeal upper airway accompanied by induced vibrations of the soft tissues (e.g., soft palate). The knowledge of the tissue behavior subject to a particular airflow is relevant for realistic clinic applications. However, in-vivo measurements are usually impractical. The goal of the present study is to develop a 3D fluid-structure interaction model for the human uvulopalatal system relevant to OSA based on simplified geometries under physiological conditions. Numerical simulations are performed to assess the influence of the different breathing conditions on the vibrational dynamics of the flexible structure. Meanwhile, the fluid patterns are investigated for the coupled fluid-structure system as well. Increasing the respiratory flow rate is shown to induce larger structural deformation. Vortex shedding induced resonance is not observed due to the large discrepancy between the flow oscillatory frequency and the natural frequency of the structure. The large deformation for symmetric breathing case under intensive respiration is mainly because of the positive feedback from the pressure differences on the top and the bottom surfaces of the structure.
阻塞性睡眠呼吸暂停综合征(OSAS)是一种常见的与睡眠相关的疾病。其特征是咽部上气道反复出现部分或完全塌陷,并伴有软组织(如软腭)的振动。了解特定气流作用下的组织行为对于实际临床应用具有重要意义。然而,体内测量通常不切实际。本研究的目的是基于生理条件下的简化几何形状,为与OSA相关的人类悬雍垂腭系统开发一个三维流固耦合模型。进行数值模拟以评估不同呼吸条件对柔性结构振动动力学的影响。同时,也对耦合流固系统的流体模式进行了研究。结果表明,增加呼吸流速会导致更大的结构变形。由于流动振荡频率与结构固有频率之间存在较大差异,未观察到涡激共振。在强烈呼吸下对称呼吸情况下的大变形主要是由于结构上下表面压力差的正反馈作用。