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可折叠管中与生物医学流动相关的屈曲临界压力。

Buckling critical pressures in collapsible tubes relevant for biomedical flows.

机构信息

Department of Engineering Mechanics, FLOW Research Center, KTH Royal Institute of Technology, 10044, Stockholm, Sweden.

出版信息

Sci Rep. 2023 Jun 8;13(1):9298. doi: 10.1038/s41598-023-36513-6.

Abstract

The behaviour of collapsed or stenotic vessels in the human body can be studied by means of simplified geometries like a collapsible tube. The objective of this work is to determine the value of the buckling critical pressure of a collapsible tube by employing Landau's theory of phase transition. The methodology is based on the implementation of an experimentally validated 3D numerical model of a collapsible tube. The buckling critical pressure is estimated for different values of geometric parameters of the system by treating the relation between the intramural pressure and the area of the central cross-section as the order parameter function of the system. The results show the dependence of the buckling critical pressures on the geometric parameters of a collapsible tube. General non-dimensional equations for the buckling critical pressures are derived. The advantage of this method is that it does not require any geometric assumption, but it is solely based on the observation that the buckling of a collapsible tube can be treated as a second-order phase transition. The investigated geometric and elastic parameters are sensible for biomedical application, with particular interest to the study of the bronchial tree under pathophysiological conditions like asthma.

摘要

人体中塌陷或狭窄的血管的行为可以通过简化的几何形状(如可折叠管)进行研究。这项工作的目的是通过采用朗道相变理论来确定可折叠管的屈曲临界压力值。该方法基于实现经过实验验证的可折叠管的 3D 数值模型。通过将腔内压力与中央横截面面积之间的关系视为系统的序参量函数,针对系统的不同几何参数值来估计屈曲临界压力。结果显示了屈曲临界压力与可折叠管几何参数的依赖性。推导出了一般的无量纲屈曲临界压力方程。该方法的优点是它不需要任何几何假设,而是仅仅基于这样的观察,即可折叠管的屈曲可以被视为二阶相变。研究的几何和弹性参数对于生物医学应用是敏感的,特别是对于哮喘等病理生理条件下支气管树的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20a4/10250313/8509506dc581/41598_2023_36513_Fig1_HTML.jpg

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