Santos-Ortega Álvaro, Alba-Linero Carmen, Urbinati Facundo, Rocha-de-Lossada Carlos, Orti Rafael, Reyes-Bueno José Antonio, Garzón-Maldonado Francisco Javier, Serrano Vicente, de Rojas-Leal Carmen, de la Cruz-Cosme Carlos, España-Contreras Manuela, Rodríguez-Calvo-de-Mora Marina, García-Casares Natalia
Department of Ophthalmology, Hospital Costa del Sol, 29603 Malaga, Spain.
Department of Ophthalmology, Hospital Universitario Virgen de la Victoria, 29010 Malaga, Spain.
J Clin Med. 2023 Nov 10;12(22):7035. doi: 10.3390/jcm12227035.
Our objective is to analyze retinal changes using optical coherence tomography angiography (OCT-A) in patients with mild cognitive impairment (MCI) to characterize structural and vascular alterations. This cross-sectional study involved 117 eyes: 39 eyes from patients with MCI plus diabetes (DM-MCI), 39 eyes from patients with MCI but no diabetes (MCI); and 39 healthy control eyes (C). All patients underwent a visual acuity measurement, a structural OCT, an OCT-A, and a neuropsychological examination. Our study showed a thinning of retinal nerve fiber layer thickness (RNFL) and a decrease in macular thickness when comparing the MCI-DM group to the C group ( = 0.008 and = 0.016, respectively). In addition, an increase in arteriolar thickness ( = 0.016), a reduction in superficial capillary plexus density ( = 0.002), and a decrease in ganglion cell thickness ( = 0.027) were found when comparing the MCI-DM group with the MCI group. Diabetes may exacerbate retinal vascular changes when combined with mild cognitive impairment.
我们的目标是使用光学相干断层扫描血管造影（OCT-A）分析轻度认知障碍（MCI）患者的视网膜变化，以表征其结构和血管改变。这项横断面研究纳入了117只眼：39只眼来自患有MCI加糖尿病的患者（DM-MCI），39只眼来自患有MCI但无糖尿病的患者（MCI）；以及39只健康对照眼（C）。所有患者均接受了视力测量、结构OCT、OCT-A和神经心理学检查。我们的研究表明，将MCI-DM组与C组进行比较时，视网膜神经纤维层厚度（RNFL）变薄，黄斑厚度降低（分别为P = 0.008和P = 0.016）。此外，将MCI-DM组与MCI组进行比较时，发现小动脉厚度增加（P = 0.016），浅表毛细血管丛密度降低（P = 0.002），神经节细胞厚度降低（P = 0.027）。糖尿病与轻度认知障碍合并时可能会加剧视网膜血管变化。
Zotero 插件
