Wang T Y, Kawaguchi T P
Ann Clin Lab Sci. 1986 Nov-Dec;16(6):461-6.
The measurement was evaluated of serum prostate specific antigen (PSA) and prostatic acid phosphatase (PAP) levels for early detection of prostate cancer on a potentially high-risk group. A PSA level at 5.0 ng per ml and PAP at 4.0 ng per ml were chosen as the cut-off levels. Results obtained for PSA and PAP can be divided into three groups: Group I, with normal levels of PSA and PAP; Group II, with elevated PSA but normal PAP level; and Group III, with elevated levels of both PSA and PAP. Forty-five of 46 patients in Group I were diagnosed as normal, while 70 out of 99 patients in Group II were categorized as having prostatic carcinoma with stages ranging from A1 to D, and nine of nine patients in Group III had stage D carcinoma. Our results also indicated that the measurement of PSA had a greater sensitivity than that of PAP and that PSA measurement could be a valuable adjunct to the diagnosis of prostate cancer.
对一组潜在高危人群进行血清前列腺特异性抗原（PSA）和前列腺酸性磷酸酶（PAP）水平的检测，以早期发现前列腺癌。选择PSA水平为5.0 ng/ml和PAP水平为4.0 ng/ml作为临界值。PSA和PAP的检测结果可分为三组：第一组，PSA和PAP水平正常；第二组，PSA升高但PAP水平正常；第三组，PSA和PAP水平均升高。第一组46例患者中有45例被诊断为正常，第二组99例患者中有70例被归类为患有前列腺癌，分期从A1到D，第三组9例患者均为D期癌。我们的结果还表明，PSA检测的敏感性高于PAP检测，并且PSA检测可能是前列腺癌诊断的一项有价值的辅助手段。
