塞尔维亚双相障碍患者的非靶向脂质组学研究。

Untargeted Lipidomics Study of Bipolar Disorder Patients in Serbia.

机构信息

University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Njegoševa 12, 11000 Belgrade, Serbia.

University of Belgrade-Faculty of Medicine, Institute of Medical Chemistry, Višegradska 26, 11000 Belgrade, Serbia.

出版信息

Int J Mol Sci. 2023 Nov 7;24(22):16025. doi: 10.3390/ijms242216025.

DOI:10.3390/ijms242216025

PMID:38003221

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10671390/

Abstract

The Lipidomic profiles of serum samples from patients with bipolar disorder (BD) and healthy controls (C) were explored and compared. The sample cohort included 31 BD patients and 31 control individuals. An untargeted lipidomics study applying liquid chromatography (LC) coupled with high-resolution mass spectrometry (HRMS) was conducted to achieve the lipid profiles. Multivariate statistical analyses (principal component analysis and partial least squares discriminant analysis) were performed, and fifty-six differential lipids were confirmed in BD and controls. Our results pointed to alterations in lipid metabolism, including pathways of glycerophospholipids, sphingolipids, glycerolipids, and sterol lipids, in BD patient sera. This study emphasized the role of lipid pathways in BD, and comprehensive research using the LC-HRMS platform is necessary for future application in the diagnosis and improvement of BD treatments.

摘要

对双相情感障碍（BD）患者和健康对照（C）的血清样本进行脂质组学分析和比较。样本队列包括 31 名 BD 患者和 31 名对照个体。采用液相色谱（LC）结合高分辨率质谱（HRMS）进行非靶向脂质组学研究，以获得脂质谱。进行多变量统计分析（主成分分析和偏最小二乘判别分析），并在 BD 和对照组中确认了 56 种差异脂质。我们的结果表明，BD 患者血清中的脂质代谢发生改变，包括甘油磷脂、鞘脂、甘油酯和固醇脂质途径。本研究强调了脂质途径在 BD 中的作用，需要使用 LC-HRMS 平台进行综合研究，以将其应用于 BD 的诊断和治疗改善。