Department of Nephrology, Radboud Research Institute for Medical Innovation, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
Int J Mol Sci. 2023 Nov 16;24(22):16419. doi: 10.3390/ijms242216419.
Excessive activation of the immune system is the cause of a wide variety of renal diseases. However, the pathogenic mechanisms underlying the aberrant activation of the immune system in the kidneys often remain unknown. TRPC6, a member of the Ca-permeant family of TRPC channels, is important in glomerular epithelial cells or podocytes for the process of glomerular filtration. In addition, TRPC6 plays a crucial role in the development of kidney injuries by inducing podocyte injury. However, an increasing number of studies suggest that TRPC6 is also responsible for tightly regulating the immune cell functions. It remains elusive whether the role of TRPC6 in the immune system and the pathogenesis of renal inflammation are intertwined. In this review, we present an overview of the current knowledge of how TRPC6 coordinates the immune cell functions and propose the hypothesis that TRPC6 might play a pivotal role in the development of kidney injury via its role in the immune system.
免疫系统的过度激活是多种肾脏疾病的原因。然而，肾脏中免疫异常激活的发病机制往往尚不清楚。TRPC6 是钙通透型 TRPC 通道家族的一员，在肾小球上皮细胞或足细胞的肾小球滤过过程中很重要。此外，TRPC6 通过诱导足细胞损伤在肾脏损伤的发展中起着至关重要的作用。然而，越来越多的研究表明，TRPC6 也负责严格调节免疫细胞的功能。TRPC6 在免疫系统中的作用和肾脏炎症的发病机制是否相互交织仍不清楚。在这篇综述中，我们概述了目前关于 TRPC6 如何协调免疫细胞功能的知识，并提出了假设，即 TRPC6 可能通过其在免疫系统中的作用在肾脏损伤的发展中发挥关键作用。
