瞬时受体电位经典通道 6（TRPC6）通过调节足细胞肌动蛋白细胞骨架重排在糖尿病肾病中的作用。
Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement.
机构信息
Beijing Key Laboratory for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China.
Beijing University of Chinese Medicine, Beijing 100029, China.
出版信息
J Diabetes Res. 2020 Jan 3;2020:6897390. doi: 10.1155/2020/6897390. eCollection 2020.
Podocyte injury is an important pathogenesis step causing proteinuric kidney diseases such as diabetic kidney disease (DKD). Actin cytoskeleton rearrangement in podocyte induced by multiple pathogenic factors is believed to be the key process resulting in glomerular injury. Many studies have recently shown that transient receptor potential canonical channel 6 (TRPC6) in podocyte plays a critical role in the development and progression of proteinuric kidney disease by regulating its actin cytoskeleton rearrangement. This review is aimed at summarizing the role of TRPC6 on DKD by regulating the podocyte actin cytoskeleton rearrangement, thereby help further broaden our views and understanding on the mechanism of DKD and provide a theoretic basis for exploring new therapeutic targets for DKD patients.
足细胞损伤是导致蛋白尿性肾脏疾病（如糖尿病肾病）的重要发病机制步骤。多种致病因素诱导的足细胞肌动蛋白细胞骨架重排被认为是导致肾小球损伤的关键过程。最近的许多研究表明，足细胞中的瞬时受体电位经典通道 6（TRPC6）通过调节其肌动蛋白细胞骨架重排，在蛋白尿性肾脏疾病的发生和发展中起关键作用。本综述旨在总结 TRPC6 通过调节足细胞肌动蛋白细胞骨架重排在 DKD 中的作用，从而帮助进一步拓宽我们对 DKD 机制的认识和理解，并为探索 DKD 患者新的治疗靶点提供理论基础。
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