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肉瘤治疗的下一个前沿领域:数字健康、人工智能与精准医学探索

The Next Frontier in Sarcoma Care: Digital Health, AI, and the Quest for Precision Medicine.

作者信息

Fuchs Bruno, Studer Gabriela, Bode-Lesniewska Beata, Heesen Philip

机构信息

Sarcoma Service, University Teaching Hospital LUKS, University of Lucerne, 6000 Lucerne, Switzerland.

Sarcoma Service, Kantonsspital Winterthur, 8400 Winterthur, Switzerland.

出版信息

J Pers Med. 2023 Oct 25;13(11):1530. doi: 10.3390/jpm13111530.


DOI:10.3390/jpm13111530
PMID:38003845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10672685/
Abstract

The landscape of sarcoma care is on the cusp of a transformative era, spurred by the convergence of digital health and artificial intelligence (AI). This perspectives article explores the multifaceted opportunities and challenges in leveraging these technologies for value-based, precision sarcoma care. We delineate the current state-of-the-art methodologies and technologies in sarcoma care and outline their practical implications for healthcare providers, administrators, and policymakers. The article also addresses the limitations of AI and digital health platforms, emphasizing the need for high-quality data and ethical considerations. We delineate the promise held by the synergy of digital health platforms and AI algorithms in enhancing data-driven decision-making, outcome analytics, and personalized treatment planning. The concept of a sarcoma digital twin serves as an illustrative paradigm for this integration, offering a comprehensive, patient-centric view of the healthcare journey. The paper concludes with proposals for future research aimed at advancing the field, including the need for randomized controlled trials or target trial emulations and studies focusing on ethical and economic aspects. While the road to this transformative care is laden with ethical, regulatory, and practical challenges, we believe that the potential benefits far outweigh the obstacles. We conclude with a call to action for multidisciplinary collaboration and systemic adoption of these technologies, underscoring the urgency to act now for the future betterment of sarcoma care and healthcare at large.

摘要

在数字健康与人工智能(AI)融合的推动下,肉瘤护理领域正处于变革时代的风口浪尖。这篇观点文章探讨了利用这些技术实现基于价值的精准肉瘤护理所面临的多方面机遇与挑战。我们阐述了肉瘤护理领域当前的先进方法和技术,并概述了它们对医疗服务提供者、管理人员和政策制定者的实际影响。文章还讨论了人工智能和数字健康平台的局限性,强调了高质量数据和伦理考量的必要性。我们描述了数字健康平台与人工智能算法协同作用在加强数据驱动决策、结果分析和个性化治疗规划方面的前景。肉瘤数字孪生概念是这种整合的一个示例性范例,提供了以患者为中心的全面医疗保健历程视图。本文最后提出了推进该领域未来研究的建议,包括进行随机对照试验或目标试验模拟以及侧重于伦理和经济方面研究的必要性。尽管通往这种变革性护理的道路充满伦理、监管和实际挑战,但我们相信潜在收益远远超过障碍。我们最后呼吁进行多学科合作并系统采用这些技术,强调为了肉瘤护理及整个医疗保健的未来改善现在就采取行动的紧迫性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4491/10672685/0d071f4b4b47/jpm-13-01530-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4491/10672685/0d071f4b4b47/jpm-13-01530-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4491/10672685/0d071f4b4b47/jpm-13-01530-g001.jpg

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引用本文的文献

[1]
Diagnostic Delay in Soft Tissue Sarcomas: A Review.

Cancers (Basel). 2025-5-31

[2]
From virtual to reality: innovative practices of digital twins in tumor therapy.

J Transl Med. 2025-3-19

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[4]
Beyond the sarcoma center: establishing the Sarcoma HASM network-a Hub and Spoke Model network for global integrated and precision care.

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[5]
From Data Integration to Precision Medicine: A Value-Based Healthcare Approach for Sarcoma Care.

J Clin Med. 2024-10-30

[6]
Real-World-Time Data and RCT Synergy: Advancing Personalized Medicine and Sarcoma Care through Digital Innovation.

Cancers (Basel). 2024-7-11

[7]
Joint Expedition: Exploring the Intersection of Digital Health and AI in Precision Medicine with Team Integration.

J Pers Med. 2024-4-4

[8]
Transformative Potential of AI in Healthcare: Definitions, Applications, and Navigating the Ethical Landscape and Public Perspectives.

Healthcare (Basel). 2024-1-5

[9]
Toward Digital Twin Development for Implant Placement Planning Using a Parametric Reduced-Order Model.

Bioengineering (Basel). 2024-1-16

本文引用的文献

[1]
Unlocking the Power of Benchmarking: Real-World-Time Data Analysis for Enhanced Sarcoma Patient Outcomes.

Cancers (Basel). 2023-9-2

[2]
Artificial Intelligence and Machine Learning in Clinical Medicine, 2023.

N Engl J Med. 2023-3-30

[3]
The Sarcoma-Specific Instrument to Longitudinally Assess Health-Related Outcomes of the Routine Care Cycle.

Diagnostics (Basel). 2023-3-22

[4]
How to regulate evolving AI health algorithms.

Nat Med. 2023-1

[5]
Management and outcomes of adolescent and young adult sarcoma patients: results from the French nationwide database NETSARC.

BMC Cancer. 2023-1-20

[6]
Quality of Sarcoma Care: Longitudinal Real-Time Assessment and Evidence Analytics of Quality Indicators.

Cancers (Basel). 2022-12-22

[7]
SELNET clinical practice guidelines for bone sarcoma.

Crit Rev Oncol Hematol. 2022-6

[8]
Improving at a nationwide level the management of patients with sarcomas with an expert network.

Ann Oncol. 2022-6

[9]
AI in health and medicine.

Nat Med. 2022-1

[10]
Development of a value-based healthcare delivery model for sarcoma patients.

Swiss Med Wkly. 2021-12-24

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