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基于拉曼光谱的代谢综合征演化过程中脂肪酸结合蛋白的鉴定。

Fatty Acid-Binding Proteins Identification during the Evolution of Metabolic Syndrome: A Raman Spectroscopy-Based Approach.

机构信息

Facultad de Medicina, Universidad Autónoma de San Luis Potosí, Av. Venustiano Carranza 2405, Lomas los Filtros, San Luis Potosí 78210, Mexico.

Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACyT), Universidad Autónoma de San Luis Potosí, Av. Sierra Leona 550, San Luis Potosí 78210, Mexico.

出版信息

Molecules. 2023 Nov 8;28(22):7472. doi: 10.3390/molecules28227472.

DOI:10.3390/molecules28227472
PMID:38005194
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10672738/
Abstract

Excess fat in abdominal deposits is a risk factor for multiple conditions, including metabolic syndrome (MetS); lipid metabolism plays an essential role in these pathologies; fatty acid-binding proteins (FABPs) are dedicated to the cytosolic transport of fat. FABP4, whose primary source is adipose tissue, is released into the circulation, acting as an adipokine, while FABP5 also accompanies the adverse effects of MetS. FABP4 and 5 are potential biomarkers of MetS, but their behavior during syndrome evolution has not been determined. Raman spectroscopy has been applied as an alternative method to disease biomarker detection. In this work, we detected spectral changes related to FABP4 and 5 in the serum at different points of time, using an animal model of a high-fat diet-induced MetS. FABP4 and 5 spectral changes show a contribution during the evolution of MetS, which indicates alteration to a molecular level that predisposes to established MetS. These findings place FABPs as potential biomarkers of MetS and Raman spectroscopy as an alternative method for MetS assessment.

摘要

腹部脂肪堆积是多种疾病的危险因素，包括代谢综合征（MetS）；脂代谢在这些病理中起着至关重要的作用；脂肪酸结合蛋白（FABP）专门负责细胞质内的脂肪运输。FABP4 的主要来源是脂肪组织，它会被释放到循环中，作为一种脂肪细胞因子发挥作用，而 FABP5 也伴随着 MetS 的不良影响。FABP4 和 FABP5 是 MetS 的潜在生物标志物，但它们在综合征发展过程中的行为尚未确定。拉曼光谱已被用作疾病生物标志物检测的替代方法。在这项工作中，我们使用高脂肪饮食诱导的 MetS 动物模型，在不同时间点检测了血清中与 FABP4 和 FABP5 相关的光谱变化。FABP4 和 FABP5 的光谱变化在 MetS 的发展过程中显示出一定的贡献，这表明在分子水平上发生了改变，从而导致了已建立的 MetS。这些发现将 FABPs 作为 MetS 的潜在生物标志物，并将拉曼光谱作为 MetS 评估的替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f43/10672738/4618d177dcc4/molecules-28-07472-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f43/10672738/cbc271e1acee/molecules-28-07472-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f43/10672738/7aa8a4d7a1fe/molecules-28-07472-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f43/10672738/43f9a97b55e3/molecules-28-07472-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f43/10672738/47e9f7953f92/molecules-28-07472-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f43/10672738/3d414231eb7c/molecules-28-07472-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f43/10672738/4618d177dcc4/molecules-28-07472-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f43/10672738/cbc271e1acee/molecules-28-07472-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f43/10672738/0970ba27f625/molecules-28-07472-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f43/10672738/fd03d894bcaa/molecules-28-07472-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f43/10672738/7aa8a4d7a1fe/molecules-28-07472-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f43/10672738/43f9a97b55e3/molecules-28-07472-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f43/10672738/47e9f7953f92/molecules-28-07472-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f43/10672738/3d414231eb7c/molecules-28-07472-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f43/10672738/4618d177dcc4/molecules-28-07472-g008.jpg

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本文引用的文献

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Sci Rep. 2021 Feb 17;11(1):4008. doi: 10.1038/s41598-021-83494-5.
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Analytical performance of Raman spectroscopy in assaying biochemical components in human serum.拉曼光谱分析测定人血清生化成分的分析性能。
Lasers Med Sci. 2022 Feb;37(1):287-298. doi: 10.1007/s10103-021-03247-8. Epub 2021 Feb 3.
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FABP4 inhibitor attenuates inflammation and endoplasmic reticulum stress of islet in leptin receptor knockout rats.
FABP4 抑制剂可减轻瘦素受体敲除大鼠胰岛的炎症和内质网应激。
Eur Rev Med Pharmacol Sci. 2020 Dec;24(24):12808-12820. doi: 10.26355/eurrev_202012_24182.
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Independent and Distinct Associations of FABP4 and FABP5 With Metabolic Parameters in Type 2 Diabetes Mellitus.游离脂肪酸结合蛋白 4 和 5 与 2 型糖尿病代谢参数的独立且不同的相关性。
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Relationships between visceral/subcutaneous adipose tissue FABP4 expression and coronary atherosclerosis in patients with metabolic syndrome.代谢综合征患者内脏/皮下脂肪组织脂肪酸结合蛋白4（FABP4）表达与冠状动脉粥样硬化的关系。
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