Yurt R W, Shires G T
Arch Surg. 1987 Jan;122(1):111-6. doi: 10.1001/archsurg.1987.01400130117018.
Previous studies indicate that endogenous chemotaxins, such as the chemotactic factor C5a, may modulate the function of neutrophils (PMNs) and account for increased susceptibility to infection after injury. These effects were investigated by continuously infusing rats with saline or the chemotaxin formyl-methionyl-leucyl-phenylalanine (FMLP). Rats that sustained a full-thickness burn covering 30% of total body surface area and whose wounds were inoculated with Pseudomonas aeruginosa had a significantly shorter survival when FMLP was infused (6.5 +/- 0.91 days) than did saline-infused rats (9.9 +/- 0.83 days). Rats infused with FMLP had significantly more leukocytes in their burn wounds, significantly fewer PMNs in the circulating pool, and the same number of PMNs at the site of FMLP infusion compared with the saline-treated group. These findings support the hypothesis that chemotaxins generated by tissue injury or sepsis contribute to increased susceptibility to infection.
先前的研究表明，内源性趋化因子，如趋化因子C5a，可能会调节中性粒细胞（PMNs）的功能，并导致受伤后感染易感性增加。通过向大鼠持续输注生理盐水或趋化因子甲酰甲硫氨酰亮氨酰苯丙氨酸（FMLP）来研究这些作用。全身表面积30%遭受全层烧伤且伤口接种铜绿假单胞菌的大鼠，输注FMLP时的存活时间（6.5±0.91天）显著短于输注生理盐水的大鼠（9.9±0.83天）。与生理盐水处理组相比，输注FMLP的大鼠烧伤伤口中的白细胞显著增多，循环池中的中性粒细胞显著减少，而在FMLP输注部位的中性粒细胞数量相同。这些发现支持了以下假设：组织损伤或脓毒症产生的趋化因子会导致感染易感性增加。
