Hachinski V C, Potter P, Merskey H
Arch Neurol. 1987 Jan;44(1):21-3. doi: 10.1001/archneur.1987.00520130013009.
Problems in the literature in the appraisal of brain deep white-matter changes are considered. The identification of the changes with Binswanger's disease alone is rejected, and evidence is reviewed that demonstrates that they are associated with cognitive impairment and, to some extent, with vascular disease. Possible causes of white-matter changes and their relationships to Alzheimer's disease are examined, and it is argued that a neutral term, exact enough to define white-matter changes, sufficient as a description or label, and demanding enough to require precise clinical and imaging descriptions is needed. We suggest herein the term "leuko-araiosis" on the basis of Greek etymology and Hippocratic usage.
本文探讨了脑深部白质变化评估文献中存在的问题。仅将这些变化认定为宾斯旺格病的观点被否定，文中回顾了相关证据，这些证据表明它们与认知障碍相关，且在一定程度上与血管疾病有关。文中研究了白质变化的可能原因及其与阿尔茨海默病的关系，并认为需要一个中性术语，该术语要足够精确以定义白质变化，足以作为一种描述或标签，且要求足够严格以便进行精确的临床和影像学描述。基于希腊语词源和希波克拉底的用法，我们在此建议使用术语“脑白质疏松”。
